The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $522,673 Project Grant to the University of Chicago from October 1, 2021 to September 30, 2024. The grant supports research titled "Optically-Controlled Neuromodulation with Silicon Carbide-Based Nanostructures" under the NSF Engineering program (CFDA 47.041). The grant aims to develop optically-controlled neuromodulation technologies using silicon carbide...
This National Science Foundation (NSF) Project Grant award, funded under the Engineering program (CFDA 47.041), aims to establish closed-loop hybrid intelligence (HI) by co-designing high-resolution neuromodulation and neuromorphic devices for application to cultured neurons and organoids. The key products and services to be delivered through this $200,000 award, with a performance period from June 15, 2025 to May 31, 2028, include: Developing optogenetic cell interfaces composed of close-packed...
This National Science Foundation Project Grant award of $299,126 will fund research at the University of Chicago from March 1, 2022 through February 29, 2024 to infer neuronal activity from anatomical connectivity maps in simplified neural cell cultures. The goal is to develop methods for understanding how physical wiring relates to activity in neural networks, which can later be applied to whole brain maps. Researchers will record functional activity from a 2D neural cell network, map...
This federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $220,000 to The Salk Institute for Biological Studies to develop new minimally invasive, multi-modal probe technologies for acute and chronic spinal interfacing. The project aims to fabricate high-aspect ratio, dual-modality, mechanically flexible probes that can deliver efficient optical activation of opsin-labeled neurons and simultaneous high signal-to-noise ratio...
This Project Grant award, funded by the National Science Foundation's Engineering program (CFDA 47.041), supports the development of a novel non-surgical bioelectronic brain implant technology. The $599,918 award to the Massachusetts Institute of Technology (MIT) aims to create intravenously-introduced bioelectronic devices that can autonomously implant in target brain regions without the need for invasive surgery. The proposed technology promises to enable high-resolution brain stimulation...
This Project Grant award of $420,334 from the National Science Foundation's Engineering program (CFDA 47.041) will support the development of novel microcoaxial electro-optical probes for minimally invasive interfacing with spinal neural circuits. The probes will be small, flexible, and able to simultaneously record electrophysiological activity and optically stimulate neurons in the spinal cord. The project aims to advance the engineering of high-density, multi-modal probe arrays that can be...
This $600,000 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports research at the University of Illinois at Chicago to address challenges in damaged neuron circuits by reprogramming the brain. The project aims to develop a new method to manipulate neural circuit development by transferring and replicating neural signals from one brain to another using zebrafish larvae as a model system. The long-term goal is to reconstruct maladaptive...
This $337,422 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) aims to develop a novel "neuron-to-neuron interface" that can transmit signals between individual neurons in the brains of two zebrafish larvae. The researchers at the University of Illinois seek to create a system that allows synchronized behavioral outputs in both a "sender" and "receiver" fish by transmitting neural signals optically between their...
The University of Chicago received a $3.89 million Project Grant from the National Institutes of Health National Institute of Neurological Disorders and Stroke under the 21st Century Cures Act Brain Research through Advancing Innovative Neurotechnologies program. The grant will fund research from August 2022 through August 2025 to directly measure and manipulate the spiking activity of locus coeruleus and ventral tegmental area axons in the hippocampus of mice during hippocampal-dependent...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is for the development and validation of micro-LED optoelectrode platforms to enable high-density, artifact-free neural modulation and recording in behaving animal models. The $556,525 award, effective June 1, 2025 through April 30, 2030, will support the Regents of the University of...