Project Grant 2414436
- This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
- This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $240,146 to the University of Alabama to conduct collaborative research on the effects of cellular deformation on the proliferation and motility of single cells. The research aims to engineer specialized microfluidic devices that simulate the tight spaces cells encounter in the human body, enabling the observation of how physical stress impacts cell division, movement, and...
- This $199,982 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) funds research at Wesleyan University to investigate the principles governing the interactions at the interface between different groups of cells. The project aims to understand how cells from different tissues interact and organize themselves when they come into contact, which is crucial for advancing knowledge in areas such as tissue development, wound healing, and cancer...
- The National Science Foundation awarded a $396,319 Project Grant to the University of Utah's Office of Sponsored Projects under the Engineering federal grant program (CFDA 47.041). The three-year award will support research into the regulation of cell adhesions by mechanical force from April 2021 through March 2024. As part of its mission to improve engineering research and education, the Engineering program seeks to advance understanding of fundamental engineering principles at the cellular and...
- This $400,000 Project Grant, awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041), is funding a collaborative research project at the University of Michigan to study the mechanics of tissue boundary formation. The research aims to explain how mechanical forces inside the body help shape developing tissues during early stages of life, by investigating how cells move, interact, and respond to mechanical cues during tissue formation. The 3-year project will combine...
- This federal Project Grant award of $489,874 from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports a research program at Michigan State University (MSU) to study how epithelial cells respond to prolonged mechanical loads. The central goal of the research is to characterize the "tensioning" phenomenon in epithelial cells as a protective stress response mechanism, and to delineate the underlying mechanosensing processes that mediate this response. This...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $250,120 Project Grant to Clemson University to conduct collaborative research on the effect of cellular deformation on the proliferation and motility of single cells. The goal is to engineer specialized microfluidic devices to study how physical stresses experienced by cells in the human body, such as when they move and squeeze through tight spaces, impact their ability to divide and migrate. This research aims to...
- The National Science Foundation (NSF) awarded a $297,984 Project Grant under the Engineering program (CFDA 47.041) to the University of Texas Health Science Center at Houston (UTHealth). The grant supports collaborative research to quantify the mechanical forces inside living cells and determine how changes in these forces impact the production and secretion of proteins that shape the cellular environment. The goal is to develop predictive tools using mechanical forces to control cell...
- This $476,886 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research at Boston University to develop computational models for predicting the spatiotemporal distribution of growth factors in tissue engineering scaffolds. The goal is to optimize scaffold designs to achieve optimal growth factor exposure profiles that improve tissue regeneration outcomes, particularly for cartilage repair. The research utilizes reaction-diffusion...
- This $325,044 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research to develop a new "aerodynamic fiber deposition" technology to manufacture biomimetic soft fiber-reinforced composites with spatially varying fiber arrangements. The research aims to enable the production of high-throughput, highly controlled nano/microfiber patterns that mimic the complex fiber structures found in biological tissues like skin, muscle, and...
This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research to elucidate how the fluid-like properties of tissue extracellular matrices influence cell fate decisions in response to growth factors. The $480,237 grant, awarded to The Pennsylvania State University (Penn State) on August 1, 2024, will fund the development and characterization of viscoelastic materials to study the impact of matrix viscous dissipation on cell proliferation, apoptosis, and differentiation. The research aims to advance the fundamental understanding of mechanotransduction pathways that allow cells to sense and respond to the combined effects of growth factors and matrix physical properties. This work may provide insights to guide tissue engineering and regenerative medicine applications. No sub-awards are planned under this grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $480.2k | 7/10/24 |