Project Grant 2414075

Award Date 7/1/24
Completion Date 6/30/27
Dollars Obligated $440K
Federal Grant Program
47.049
Assistance Type
Project Grant
Place of Performance
Logan, UT 84322, USA
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This $440,262 federal Project Grant award was provided by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) grant program. The award supports a collaborative research project between professors at the Georgia Institute of Technology and Utah State University to study the evolution of archaeal protein tyrosine phosphatases (PTPs), a family of enzymes crucial for cellular signaling processes. The research aims to quantitatively characterize the evolution of loop motion and allostery in these enzymes using advanced biomolecular simulations, x-ray crystallography, kinetic characterization, and NMR spectroscopy. The project will provide fundamental insight into enzyme evolution and identify features that can be exploited for protein engineering. The research further enables specialized training for graduate students in computational biophysics, structural biology, enzyme biochemistry, and NMR spectroscopy, while also supporting outreach and mentorship activities to increase participation of underrepresented students in STEM. This award is active from July 1, 2024 through June 30, 2027.

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