Yale University was awarded a $1,050,000 Project Grant from the National Science Foundation Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049) to conduct research probing the origins of intrinsic chiroptical response and the roles of extrinsic perturbations. The research will combine experimental measurements and theoretical analyses to study how atomic motions and surrounding solvent affect the chiroptical properties of molecules. Discoveries could have...
This $196,673 federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research at Yale University to develop a predictive framework for understanding how the physical microenvironment influences 3D genome organization and gene expression. The project will integrate super-resolution microscopy, genomics, biophysical modeling, and machine learning to decode the relationship between the...
This $440,262 federal Project Grant award was provided by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) grant program. The award supports a collaborative research project between professors at the Georgia Institute of Technology and Utah State University to study the evolution of archaeal protein tyrosine phosphatases (PTPs), a family of enzymes crucial for cellular signaling processes. The research aims to quantitatively...
The National Science Foundation (NSF) awarded a $498,229 Project Grant under its Mathematical and Physical Sciences program (CFDA 47.049) to Yale University. The grant will fund research to develop new mathematical and machine learning techniques for analyzing complex, high-dimensional biomedical data such as single-cell sequencing and gene regulatory networks. Key research thrusts include creating data geometric features and neural network models to characterize point cloud data, preserving...
This federal Project Grant award of $431,392, provided by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research on the conformational dynamics and evolution of archaeal protein tyrosine phosphatases (PTPs). The principal investigators from Georgia Institute of Technology and Utah State University will use advanced biomolecular simulations, X-ray crystallography, enzyme kinetics, and NMR spectroscopy to quantitatively...
The National Science Foundation (NSF) awarded a $640,000 Project Grant under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049) to Yale University. The grant supports Professor Crawford's research investigating the role of nucleotide inhibitors of protein translation encoded in microbiomes across diverse body sites. The key objectives are to characterize the structures and functions of these nucleotide translational inhibitors, understand how they are produced, and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $401,571 to Yale University to conduct research on probing the structures and hydration of biopolymers, such as proteins, DNA, and RNA, at aqueous interfaces using chiral-selective vibrational sum frequency generation (chiral SFG) spectroscopy. The key objectives of this 5-year project are to investigate how the asymmetric chemical...
This National Science Foundation Project Grant of $536,946 will support research at the University of California, San Diego from September 2022 through August 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). The award will fund the development of rigorous scientific theories and powerful computational tools to model biomolecular interactions. Researchers will design advanced numerical methods to simulate drug and protein binding/unbinding kinetics, incorporating molecular...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) supports research to develop new mathematical tools and understanding of the long-term dynamics and rigidity of certain infinite-volume mathematical systems. The $300,000 award to Yale University, to be completed by June 30, 2028, focuses on advancing the frontier of pure mathematics, with the goal of enabling applications in areas like data encryption, navigation, and...
This $486,845 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports Professor Xiaolin Cheng of Ohio State University in developing computational tools and a theoretical framework for analyzing allosteric regulation in proteins. The research aims to advance the fundamental understanding of allosteric modulation, a key mechanism of protein function and regulation with significant implications for drug discovery. The...