This $492,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research aimed at expanding the chemical space of microbial and microbiome natural products. The research will focus on three key areas: (1) eliciting and characterizing "cryptic" metabolites from diverse microbial genera, particularly those found in the human microbiome; (2) leveraging biosynthesis-guided...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $100,000.00 to Princeton University to conduct research aimed at deepening the understanding of chemical modifications on ribonucleic acid (RNA) and their role in biological processes. The key products and services to be delivered under this 3-year award, which began on February 15, 2025, are: Studying the biochemistry and structural biology of dihydrouridine...
This $306,532 federal Project Grant award from the National Science Foundation (NSF) Mathematical and Physical Sciences (CFDA 47.049) program will fund research at Yale University to investigate the role of molecular motions in the allosteric activation of the enzyme imidazole glycerol phosphate synthase. The project will utilize advanced field cycling nuclear magnetic resonance spectroscopy techniques, coupled with computational modeling, to gain unprecedented insights into the timescales and...
The National Science Foundation awarded a $138,000 Project Grant to support research titled "Understanding Protein Synthesis in Energetically Constrained Microbial Consortia" from September 1, 2021 through August 31, 2023. The grant was awarded under the Biological Sciences program (CFDA 47.074) to further the program's goals of advancing the biological sciences and strengthening the scientific enterprise through increased knowledge and understanding of major issues facing the...
This Project Grant award of $222,000 from the National Science Foundation's (NSF) Mathematical and Physical Sciences (47.049 CFDA) program supports research at Bryant University to develop new chemical biology tools for studying peptidoglycan metabolism in bacteria. Led by Dr. Christopher Reid, the project aims to expand on the team's previous work with the inhibitor masarimycin to create an array of novel glycosyl triazole and diamide compounds that can probe the degradative steps of...
This $300,000 Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program supports a research effort by Duke University to develop and apply an integrated experimental and computational approach to uncover the design principles that govern microbiome function. The key objectives are to: Elucidate the molecular-level networks and cellular processes that determine how the addition of new microbial species impacts overall microbiome function, using...
The National Institute of General Medical Sciences (NIGMS) awarded a $965,356 Project Grant (CFDA 93.859) to Northeastern University to elucidate the mechanisms that enable translation in bacterial and eukaryotic ribosomes. The 5-year project, which began on May 1, 2024, will apply state-of-the-art molecular simulation methods to study how ribosomes accurately and efficiently produce proteins in cells. The research aims to advance the understanding of ribosome dynamics, which can inform the...
This $563,387 project grant was awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) to the University of Mississippi. The grant is funding research to characterize the function of an unknown protein, BRESU_2828, that is found in many bacterial species, including some that are pathogenic to humans and crops. The project aims to investigate how this protein influences the synthesis of bacterial pili, which are surface structures used for attachment and...
This National Science Foundation (NSF) Chemical Measurements and Imaging using Novel Functional Nucleic Acids Project Grant, awarded under the Mathematical and Physical Sciences (CFDA 47.049) program, will provide $650,000 in funding from September 1, 2024 to August 31, 2027. Professors Hsin-Chih Yeh from the Department of Biomedical Engineering and Devleena Samanta from the Department of Chemistry at the University of Texas at Austin will develop new types of functional nucleic acid molecules...
The National Science Foundation awarded a $996,521 project grant under the Biological Sciences program (CFDA 47.074) to the Carnegie Institution of Washington for the period of April 1, 2021 through March 31, 2024. The goal of the research project is to scale single-cell physiology studies to better understand community stability in the natural gut microbiome. As part of this work, Johns Hopkins University will expand its microbiome curriculum to additional middle schools in Baltimore County...