This $629,995 Project Grant, awarded on September 15, 2024 by the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074), funds research at the University of Cincinnati on the role of the hormone aldosterone in regulating frog metamorphosis. The project aims to: 1) measure levels of 11 corticosteroids in tadpole plasma and tissues; 2) compare growth and development in tadpoles with and without the mineralocorticoid receptor; and 3) use RNA-sequencing to identify genes regulated by the mineralocorticoid receptor. The findings will advance understanding of how hormones modulate developmental processes that impact animal health and fitness. The project also includes training graduate and undergraduate students in amphibian research as well as developing an undergraduate lab course on gene disruption technology to engage high school students. No sub-awards are planned under this grant.
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