Under this $200,000 Project Grant from the National Science Foundation Division of Chemistry's Mathematical and Physical Sciences program (CFDA 47.049), the New Jersey Institute of Technology will collaborate with the University of Rochester and University of Virginia to investigate the supramolecular assembly of beta-sheet nanofibrils composed of mirror-image peptides. The collaborative team will determine the structure of these systems with near-atomic precision using cryo-electron...
North Carolina State University will synthesize functional biomolecules from tunable N-aryl peptide precursors under a $976,087 project grant from the National Science Foundation Division of Chemistry. The grant was awarded on May 1, 2021 for a five-year period concluding on April 30, 2026. The grant supports work under the NSF's Mathematical and Physical Sciences program (CFDA 47.049), which aims to promote progress in these scientific fields and strengthen the national scientific enterprise....
This $410,939 National Science Foundation (NSF) Project Grant awarded to Clemson University under the Biological Sciences (CFDA 47.074) program supports research to elucidate the biophysical mechanisms of membrane protein folding and stability. The project will use advanced single-molecule force spectroscopy techniques, such as atomic force microscopy, to precisely measure the forces that hold membrane proteins in their functional, folded shapes. This research aims to address fundamental...
This Project Grant award from the National Science Foundation's (NSF) Division of Chemistry Program in Mathematical and Physical Sciences (CFDA 47.049) provides $600,000 in funding to Carnegie Mellon University (CMU) to investigate how the asymmetry of cell membranes affects the phase behavior of their lipid constituents. The principal investigator, Professor Markus Deserno, will develop theoretical and computational techniques to elucidate how factors like differential stress and cholesterol...
The National Science Foundation (NSF) Division of Chemistry awarded a 3-year, $389,999 Project Grant to Florida State University (FSU) under the Mathematical and Physical Sciences program (CFDA 47.049) to develop new approaches to characterize the structural dynamics of proteins that play critical roles in chemical reactions within biological cells. The project, led by Dr. Christian Bleiholder, will combine and enhance the capabilities of tandem-ion mobility spectrometry coupled with mass...
This $360,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research by professors Eriks Rozners of SUNY at Binghamton and James A. Mackay of Elizabethtown College. The project aims to develop new peptide nucleic acid (PNA) molecules capable of selectively recognizing and binding to double-stranded non-coding RNA. This research addresses an important challenge in RNA biochemistry and could enable...
The National Science Foundation awarded a three-year $400,000 project grant to the University of Rochester under the Mathematical and Physical Sciences program (CFDA 47.049). The grant supports collaborative research between the University of Rochester, New Jersey Institute of Technology, and University of Virginia to investigate the supramolecular assembly of beta-sheet nanofibrils composed of mirror-image peptides. The team will determine the structure of these systems with near-atomic...
North Carolina State University received a $315,105 Project Grant award from the National Science Foundation on August 15, 2021 to complete work by July 31, 2024. The grant funds a collaborative research project to probe coordination specificity of metalloprotein domains with peptide-polymer amphiphile self assembly. This work will be conducted under the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049), which aims to promote progress in these scientific...
This Project Grant award from the National Science Foundation's Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports a collaborative research effort led by Emory University and the University of Illinois Chicago to design and develop peptide-based filamentous nanomaterials. The $300,000 award, effective from August 1, 2024 to July 31, 2027, will leverage computational methods to systematically explore the energetics and structural designability of...
This $140,390 Project Grant award, funded by the National Science Foundation's (NSF) Division of Materials Research under the Mathematical and Physical Sciences program (CFDA 47.049), supports research at the University of Illinois to develop porous peptide materials inspired by the modular architecture of proteins. The key objectives are to establish predictable strategies for making these porous peptide frameworks by combining peptides with tailored aromatic π-stacking groups, which are...