Project Grant 2403954

Award Date 6/15/24
Completion Date 5/31/27
Dollars Obligated $439K
Federal Grant Program
47.049
Assistance Type
Project Grant
Place of Performance
Evanston, IL 60208, USA
Similar Awards
This Project Grant award, provided by the National Science Foundation (NSF) through the Mathematical and Physical Sciences (CFDA 47.049) program, supports research on a new class of materials called protein-like polymers (PLPs). The $170,954 award funds a collaborative research effort to study how these PLP materials can mimic the structure and function of proteins, enabling them to interact with and penetrate biological membranes and cells. The goal is to elucidate the mechanisms by which...
This four-year Project Grant award of $600,000 from the National Science Foundation Division of Materials Research supports collaborative research at Northwestern University to develop high-affinity supramolecular peptide materials for selective capture and recovery of proteins. The Mathematical and Physical Sciences program (CFDA 47.049) aims to strengthen the nation's scientific enterprise through advancing knowledge and understanding of major problems. As the prime awardee, Northwestern...
This $1,500,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program will support research at Northwestern University to develop innovative protein-based biomaterials. The research aims to (1) engineer mussel foot proteins with superior underwater adhesive properties compared to wild-type sequences, and (2) create resilin-inspired bioelastomers with high strength while retaining natural mechanical resilience. The proposed...
This $500,000 federal Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) supports research at Northwestern University to develop de novo designed proteins as mechano-responsive junctions in protein-polymer networks. The key objectives are to: (i) synthesize and computationally simulate de novo designed proteins and their respective protein-polymer networks, and (ii) develop techniques for mechanical characterization...
This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049), in the amount of $642,000, will fund research at Northwestern University to develop novel hybrid protein-DNA supramolecular structures. The key objectives are to: (1) design generalizable strategies for site-specific DNA functionalization to control proteins in 1D arrays; (2) create dynamic, DNA-driven 2D protein lattices; and (3) utilize DNA interactions to facilitate...
This $173,383 federal Project Grant award was provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program. The award supports research to develop a new class of sequence-specific "peptide-based plastics" with customizable properties that can be synthesized in a scalable manner. The key technical objectives are to create high molecular weight polymer chains using modular short peptides as "macromonomers" through...
This $115,114 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research to develop and characterize novel biomaterials made from folded globular proteins. The project aims to: Experimentally characterize the mechanical response of the protein building blocks at the single-molecule level under varying force, tethering geometry, and solution conditions. Directly relate the observed domain unfolding of the...
The National Science Foundation awarded a $599,940 Project Grant to the University of Chicago under the Mathematical and Physical Sciences program (CFDA 47.049) for research titled "COLLABORATIVE RESEARCH: DMREF: GOALI: HIGH-AFFINITY SUPRAMOLECULAR PEPTIDE MATERIALS FOR SELECTIVE CAPTURE AND RECOVERY OF PROTEINS." The four-year award beginning October 1, 2021 will support the development of new high-affinity supramolecular peptide materials for selective capture and recovery of...
This $381,000 three-year Project Grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports research at Northwestern University to develop an accurate hierarchical modeling approach for understanding the structural and mechanical properties of polymer grafted nanoparticle materials. The research will employ molecular simulations, theory, and machine learning to explain how variability in nanoparticle and polymer graft size, known as dispersity,...
The National Science Foundation awarded Northwestern University a $525,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to develop protein crystallization programmed with DNA. This three-year award beginning June 1, 2021 will support research to promote progress in the mathematical and physical sciences by increasing understanding of major problems through the development of new techniques to crystallize proteins using DNA programming. The University will...

This Project Grant award, valued at $438,757.00, was provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The award supports a collaborative research project between Northwestern University and other partners to develop and investigate a new class of proteomimetic macromolecules called protein-like polymers (PLPs). The goal is to elucidate how these materials can effectively enter cells, interact with biological membranes and compartments, and serve as unique modulators of cellular function. The research aims to provide a fundamental understanding of PLP structure, dynamics, and performance in biological systems, with potential applications in areas such as drug development, cellular probes, and protein detection. The project period runs from June 2024 through May 2027.

Generated 3/18/25, 4:43 AM