Project Grant 2403840
- This $393,263 National Science Foundation Division of Chemistry Project Grant will support collaborative research between the University of California, Davis and the University of Utah to study DNA repair mechanisms. The research aims to apply a chemical biology approach to reveal insights into base excision repair glycosylases that identify and initiate repair of rare DNA bases with subtle damage. Specifically, the team will develop transition state mimics to test the idea that evolutionarily...
- Federal Project Grant Award Summary The National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), awarded $345,248 to California State University, Northridge for a three-year project (September 1, 2025 – August 31, 2028) to design and synthesize hybrid molecules capable of sequence-specific DNA recognition. Under the direction of Dr. Thomas Minehan, the project delivers carbamate nucleic acid (CNA) hybrid molecules engineered to bind...
- This $150,000 Project Grant awarded by the National Science Foundation's Mathematical and Physical Sciences (CFDA 47.049) program funds research at Vanderbilt University to elucidate the molecular mechanisms of DNA repair by a newly discovered bacterial enzyme. The project aims to understand how this enzyme protects microbes against toxic natural products, with the long-term goals of elucidating bacterial interstrand DNA crosslink repair pathways and discovering new genotoxic agents with...
- Federal Project Grant Summary The National Science Foundation (NSF) Division of Chemistry awarded $600,000 to the Research Foundation of the City University of New York (RFCUNY) under the Mathematical and Physical Sciences program (CFDA 47.049) for a three-year project (September 1, 2025 – August 31, 2028). Under the direction of Professor Mahesh Lakshman at City College of New York, this award supports the development of novel synthetic platforms and chemical methods for selective...
- The National Science Foundation's Division of Molecular and Cellular Biosciences awarded $1.1 million to the University of Massachusetts Medical School under the Biological Sciences program (CFDA 47.074) on August 1, 2025, for a five-year CAREER award extending through July 31, 2030. This Project Grant supports fundamental research investigating a newly discovered bacterial immune system called DDMDE (DNA-guided, DNA-targeting molecular defense element) to develop next-generation genome...
- The Regents of the University of California, San Francisco (UCSF) received a $284,636 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences (CFDA 47.074) federal grant program. The two-year award will support research establishing novel tools to artificially manipulate chromosome folding and modulate various genome functions, including enhancer regulation of gene expression. Specifically, the grant will fund...
- This Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $300,000 to the University of Kansas Center for Research Inc. from February 1, 2023 to January 31, 2025. The award will support research investigating delivery and trafficking of DNA introduced to cells from environmental sources using the genetically tractable organism Caenorhabditis elegans. The project aims to gain new...
- This National Science Foundation (NSF) Project Grant award, funded under the Integrative Activities program (CFDA 47.083), supports research on the structural mechanisms of bacterial extracellular DNA-recognition. The $216,149 award to the Board of Regents of the University of Nebraska, from July 1, 2023 to June 30, 2026, aims to identify and characterize novel DNA receptor subunits incorporated into bacterial surface appendages. The project will purify soluble protein constructs, measure...
- This $900,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project led by North Carolina State University to unravel the mechanisms behind the workings of the DNA mismatch repair systems. The research aims to elucidate the role of atypical nucleic acid structures, such as three-way junctions and R-loops, in driving the expansion of simple sequence repeats (SSRs) within the genome, which is a...
- Federal Grant Award Summary The University of California, San Diego received a $375,000 Project Grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). The four-year award, active from August 1, 2025 through July 31, 2029, supports collaborative research investigating analog information storage in chromatin states—specifically how cells maintain identity information through gene expression regulation...
This $663,956 Project Grant award from the National Science Foundation's (NSF) Division of Chemistry, through the Mathematical and Physical Sciences (CFDA 47.049) federal grant program, supports Professor Norbert Reich at the University of California, Santa Barbara in studying a new DNA recognition mechanism involving DNA strand separation. The key products and services to be delivered under this 3-year award include: This research has the potential for broad impact on the fundamental understanding of DNA recognition, and the training of the next generation of scientists and industry professionals.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $87.0k | 8/9/24 | ||
| Not listed | $577.0k | 4/30/24 |