The National Science Foundation (NSF) has awarded a $300,000 Project Grant under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) to the University of Notre Dame for the "POSE: PHASE I: HARMONY: HARMONIZING THE HIGH PERFORMANCE PYTHON WORKFLOW ECOSYSTEM" project. This 1-year effort seeks to harmonize Python-based workflow management, build sustainability, and better support complex computational workflows in research and commercial environments. The project aims to deliver a unified open-source software ecosystem that will integrate, interoperate, and interchange workflow components to enable high-performance computational capabilities from a familiar Python interface. Key activities include ecosystem discovery, organization, governance, and community building to establish the foundational "Harmony" open-source ecosystem. This grant award reflects NSF's mission to advance science and engineering research, innovation, and solutions to national challenges through collaborative, interdisciplinary efforts.