This National Science Foundation (NSF) Project Grant, awarded under the Mathematical and Physical Sciences (CFDA 47.049) program, provides $233,333 to The Ohio State University to develop and implement multifunctional DNA-based nanoscale devices. The goal is to detect genetic activity and control gene expression, particularly related to cell state and differentiated functions. The devices will enable mechanical control of gene regulation and provide insights into how chromatin structure and...
The Ohio State University was awarded a $299,999 Project Grant from the National Science Foundation under the Biological Sciences federal grant program (CFDA 47.074) for work on "EAGER: IIBR INFORMATICS: A REINFORCED IMPUTATION FRAMEWORK FOR ACCURATE GENE EXPRESSION RECOVERY FROM SINGLE-CELL RNA-SEQ DATA." This two-year award beginning March 1, 2021 will support the development of a new computational framework to more accurately recover gene expression profiles from single-cell RNA...
The National Science Foundation (NSF) awarded a $299,772 EAGER (Early-concept Grants for Exploratory Research) grant under the Biological Sciences program (CFDA 47.074) to Washington State University (WSU) to develop new molecular tools for identifying protein-protein interactions within specific cellular compartments in plant cells. The project, titled "TOOLS4CELLS: Bimolecular Proximity Tagging", aims to close the gap in existing methods by creating split enzyme versions that can...
This National Science Foundation Project Grant of $921,054 supports research to develop new biological functions through engineering plant hormone receptors. Led by the Regents of the University of California, Riverside under the Biological Sciences program (CFDA 47.074), the project engineers plant sensors to recognize pharmaceuticals and dietary molecules. It then uses these sensors to design "sentinel cells" that indicate molecule presence through color changes. Specifically, the...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award provides $497,039 to Valdosta State University to investigate the biochemical mechanisms by which reactive oxygen species activate the GCN2 protein kinase and its role in regulating protein synthesis in Arabidopsis thaliana as a model plant system. The research aims to enhance understanding of plant stress responses and translational control mechanisms, which could contribute to developing...
This $668,494 Project Grant awarded by the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research to systematically identify and characterize previously undetected open reading frames (ORFs) in four model plant species: Arabidopsis, tomato, rice, and maize. The project will leverage advanced experimental and computational techniques to discover these "noncanonical" ORFs, which can reveal new ways plants use proteins and control gene activities....
This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $321,802 to the University of South Alabama to characterize the components and functions of specialized membrane structures called nanodomains in plant cells. The goal is to understand how these nanodomains change in response to pathogen infections, using the model plant Arabidopsis thaliana and the crop potato. The research will employ proteomic, lipidomic, and biochemical...
The Ohio State University was awarded a $988,596 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences federal grant program (CFDA 47.074). The grant will support research from August 1, 2021 to July 31, 2025 on the structural dynamics and function of proteins using nuclear magnetic resonance spectroscopy and computational methods. The Biological Sciences program aims to advance the field and strengthen the national...
This $750,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports collaborative research on the evolution and development of fundamental plant reproductive structures called sporangia. Led by the New York Botanical Garden, this interdisciplinary project will investigate the molecular genetics of sporangium development in the model fern Ceratopteris. The research aims to elucidate the core genetic network underlying sporangium...
The National Science Foundation awarded a $400,001 Project Grant to The Ohio State University under the Biological Sciences federal grant program (CFDA 47.074) to support the growth and development of the Arabidopsis Biological Resource Center from December 1, 2021 to November 30, 2023. The Center will provide infrastructure capacity for biological research through the maintenance and expansion of biological collections to promote progress in the biological sciences. As the parent...