Project Grant 2201645

Award Date 6/15/22
Completion Date 5/31/25
Dollars Obligated $881K
Federal Grant Program
47.050
Assistance Type
Project Grant
Place of Performance
Los Angeles, CA 90095, USA
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This National Science Foundation Project Grant of $880,632 supports research into drivers and effects of latent phage activation in marine SAR11 bacteria. Funded under the Geosciences program (CFDA 47.050), this three-year award to the University of California, Los Angeles will fill critical knowledge gaps about host-virus interactions in the global oceans.

Through field surveys, laboratory experiments, and mathematical modeling, the grantee will quantify the frequency of prophage infections in SAR11 bacteria using long-read metagenomic sequencing. Controlled growth experiments under varying physical, chemical, and biological stress conditions will identify factors triggering prophage activation and shifts in gene expression. Outcomes from cultured prophage-host systems will parameterize models to predict infection dynamics in diverse marine ecosystems. This research aims to revise estimates of prophage activation in the abundant SAR11 bacteria and enhance understanding and predictive capacity for host-virus interactions under changing environmental conditions.

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