This National Science Foundation (NSF) Faculty Early Career Development (CAREER) Program grant, with CFDA number 47.083 - Integrative Activities, will support research to improve understanding of how osteocytes (strain-sensing cells embedded in bone tissue) regulate bone material properties and fracture resistance. The $342,516 award to Montana State University, with a period of performance from Sep 1, 2024 to Aug 31, 2029, will pursue two main objectives: 1) determining the impacts of direct and indirect osteocyte regulatory activities on bone matrix composition, material properties, and fracture toughness; and 2) defining the metabolic processes that underpin different osteocyte matrix regulatory activities. The research aims to lay the foundation for developing new therapies that target improving bone matrix quality by modulating osteocyte activities and metabolic processes. The project will also engage underrepresented undergraduate and graduate students in research, integrate research findings into courses, and build research capacity at Montana State University.
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