This $509,070 Project Grant award from the National Science Foundation's Division of Molecular and Cellular Biosciences (CFDA 47.074 Biological Sciences) supports research at Purdue University to explore the working mechanism of CRISPR-Cas12 endonucleases and analogues. The primary goals are to investigate the regulatory mechanisms of natural CRISPR inhibitor proteins, and to dissect the structural dynamics of newly identified Cas12 analogues found in mobile genetic elements and viruses. This research aims to expand knowledge in genome editing and promote community awareness of CRISPR technology. The project also includes an educational component to enrich understanding of CRISPR among students at Purdue, K-12 learners, and the general public through outreach programs. No subawards are planned under this award, which runs from January 1, 2024 through December 31, 2028.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $509.1k | 1/25/24 |