This Project Grant award of $275,000, funded by the National Science Foundation (NSF) under the CFDA program 47.084 "NSF Technology, Innovation, and Partnerships", aims to develop improved bacterial strains for more cost-effective production of proteins used in detergents, personal care products, and dairy. The project seeks to identify superior bacterial hosts and develop advanced genetic engineering tools to convert these bacteria into efficient protein factories. The goal is to...
This Project Grant award of $575,765, provided by the National Science Foundation (NSF) Engineering program (CFDA 47.041), supports research at Northeastern University to enhance the production of biochemicals from sustainable single-carbon (C1) feedstocks using acetogenic bacteria. The key objectives are to 1) understand the metabolic and regulatory mechanisms by which acetogens leverage multiple substrates simultaneously to overcome growth limitations, and 2) apply this knowledge to direct...
This Project Grant award from the U.S. Department of Energy's Office of Science Financial Assistance Program (CFDA 81.049) provides $199,722.00 to Bluestem Biosciences Inc. on July 10, 2023. The funding will support the company's work to develop commercial-scale anaerobic fermentation processes to biosynthesize 3-hydroxypropionate, a valuable chemical building block. This aligns with the Office of Science's mission to advance scientific understanding and technological innovation, particularly in...
This Project Grant award of $275,000.00 from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop a novel platform for accelerated strain development for precision fermentation to enable high-yield production of animal proteins in yeast. The key objectives of this award are to: 1) Develop a high-throughput sequence screening approach to identify high-expression proteins and signal peptides, 2) Train an AI model to...
This Project Grant award of $538,791 from the National Science Foundation's Engineering program (CFDA 47.041) will fund research by the University of Colorado to develop novel electrocatalysts for converting bio-derived carboxylic acids, such as lactic acid, into alcohols like propylene glycol. The goal is to create a more sustainable alternative to current petrochemical-based processes for manufacturing high-volume commodity chemicals. The project will explore using...
This $2,526,095 Cooperative Agreement awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop a highly efficient, cell-free enzymatic cascade system for the electrochemical conversion of carbon dioxide (CO2) into methanol. The project, led by Arzeda Corp, a biotechnology company in Seattle, Washington, seeks to achieve energy efficiencies exceeding 70% by integrating AI-driven enzyme design, synthetic chemistry,...
This Cooperative Agreement award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program provides $2,233,515 to Arzeda Corp to develop a biocatalytic process for producing bio-based acrylate monomers. The project aims to transform the production of acrylates, which are high-value chemicals used in paints, plastics, and absorbent materials, by leveraging artificial intelligence-driven protein engineering to create stable,...
This $1,700,000 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will support research to develop a bioelectrochemical process to capture and recycle carbon dioxide (CO2) into high-value chemicals using microbes. The project aims to create a circular economy by transforming CO2 into acetic acid, which will then be used as a feedstock for engineered Escherichia coli strains to produce sustainable biomaterials. Key activities include developing...
The U.S. Department of Agriculture's Rural Business Cooperative Services awarded a $10,000,000 Project Grant under the Biobased Market Development and Access Grant Program (CFDA 10.376) to Bluestem Biosciences Inc., a for-profit entity based in Omaha, Nebraska. The grant, awarded on January 16, 2025, with a completion date of January 16, 2027, supports the development of advanced biomanufacturing technologies, including anaerobic fermentation, yeast microbe modification, and cellulosic...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $274,918 to Cascade Biocatalysts Inc. will fund research and development to demonstrate the commercial feasibility and scalability of a patent-pending approach for stabilizing enzymes through engineered polymer-enzyme interactions. The goal is to enable environmentally sustainable, low-carbon chemical manufacturing processes that utilize enzymes as catalysts, which can decrease...