This National Science Foundation (NSF) Engineering Program (CFDA 47.041) Project Grant award of $600,000 to Dartmouth College aims to develop methodologies for efficiently manufacturing mature human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to accelerate drug development and cardiac disease modeling. The project will employ biochip design, machine learning, developmental biology, and tissue engineering approaches to enhance the structural and functional maturity of hiPSC-CMs, which are currently limited in their ability to accurately model heart disease. The award includes a $187,857 sub-award to Michigan State University to contribute expertise in this research. The project has an anticipated completion date of Aug 31, 2027.