The National Science Foundation awarded a $138,000 Project Grant to support research from June 2021 to May 2023 titled "Uncovering the Molecular Mechanisms of Mitochondrial Proteostasis." The grant was awarded under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the Nation's scientific enterprise through increasing knowledge and enhancing understanding of major problems. Funds will support the grantee's research...
This $1,000,000 four-year Project Grant from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund research at Northeastern University exploring the role of mitochondria in regulating cell fate decisions during early mammalian development. Specifically, the researchers will test the hypothesis that differential allocation of mitochondrial subtypes, which vary in biochemical properties and protein content including levels of the transcription factor TEAD4,...
This Project Grant award from the National Science Foundation (NSF) under the Integrative Activities program (CFDA 47.083) provides $150,000.00 to the University of South Alabama to enhance the natural repair mechanisms of mitochondrial DNA (mtDNA) and improve the targeting of key repair enzymes to mitochondria. The project aims to re-engineer the mitochondrial localization signals of five DNA glycosylases to increase their efficiency in repairing oxidative damage to mtDNA, which can lead to...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $373,129 to support research on the mechanisms of mitophagy, a type of mitochondrial quality control, and its role in maintaining tissue health and homeostasis. The 5-year project, awarded to Wayne State University, aims to generate genetic tools to manipulate different forms of mitophagy in fruit flies and investigate the...
This $999,996 Project Grant award, provided by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), supports fundamental research aimed at generating "designer mitochondria" for biotechnology, healthcare, and basic research applications. The key objectives are to identify the factors required for human mitochondrial DNA (mtDNA) replication and characterize the mechanisms underlying the species-specificity of this process. This work represents a critical step...
This $900,052 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences will fund research into the molecular mechanisms governing cytoskeleton-mediated motility and distribution of peroxisomes and mitochondria in plants. The grant supports three years of collaborative research between Michigan State University and its sub-awardee to advance understanding of how these organelles recruit cytoskeletal motor proteins for directional transport along...
This Project Grant award from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) provides $949,958 in funding to Rutgers, The State University of New Jersey, Camden Division to conduct research on the role of inorganic polyphosphate (polyP) in regulating mitochondrial physiology in mammals. The project aims to elucidate the molecular mechanisms by which polyP influences mitochondrial bioenergetics in normal and...
The National Science Foundation (NSF) has awarded a $236,098 CAREER grant under the Biological Sciences program (CFDA 47.074) to the University of California, Berkeley. The project, titled "CAREER: Mitochondrial Genome Partitioning and Quality Control," aims to investigate the mechanisms of mitochondrial genome inheritance and how it relates to mitochondrial function. The research will reveal how mitochondrial DNA transmission is linked to mitochondrial dynamics, identify molecular...
This $777,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is funding a research project at the University of Washington to understand the cellular mechanisms that regulate mitochondrial DNA (mtDNA) heteroplasmy and its relationship to mitochondrial quality control pathways. The key objectives are: 1) using single-cell sequencing to test hypotheses about how mitochondrial quality control...
This $899,894 Project Grant award from the National Science Foundation's (NSF) Integrative Activities (IA) program, CFDA 47.083, will support research to characterize the structure, membrane topology, substrate specificity, and biochemical properties of a unique mitochondrial HAD phosphatase enzyme in a divergent unicellular organism. The project aims to elucidate the dual functional roles of this enzyme, which may provide insights into the broader cellular functions of the related TIM50 protein...