Project Grant 2322946
- Federal Grant Award Summary The National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded $199,991 to the University of Michigan-Dearborn under the Engineering program (CFDA 47.041) on May 15, 2026, through an Engineering Research Initiation (ERI) grant. This two-year project, with completion scheduled for April 30, 2028, will deliver a novel microphysiological system that simulates the brain's cerebrospinal fluid (CSF) environment and...
- The National Science Foundation awarded a $514,591 Project Grant to the Regents of the University of California at Riverside under the Engineering program (CFDA 47.041) for the period of April 1, 2021 through March 31, 2026. The grant funds the CAREER: MECHANOAGING: UNDERSTANDING THE MECHANICAL FORCES THAT DRIVE CELLULAR AGING project. This project will investigate how mechanical forces impact the aging process at the cellular level. The Engineering program seeks to improve quality of life and...
- This five-year, $649,659 National Science Foundation Engineering Project Grant will support research at the Massachusetts Institute of Technology to advance fundamental understanding of the tissues that produce voluntary movement in humans and other biological creatures. Specifically, the grant will fund experiments studying how mechanical signaling coordinates assembly, maturation and repair at the neuromuscular interface in both physiological and pathological states. The principal investigator...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
- The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $135,000 Project Grant to the University of Central Florida (UCF) for the project "COLLABORATIVE RESEARCH: EAGER: 3D BIOPRINTED ORGANOIDS FOR STUDYING THE MECHANISM OF CEREBROVASCULAR AGING". This award supports the development of 3D bioprinted cerebrovascular organoids derived from human induced pluripotent stem cells to study the impact of cellular senescence...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the Regents of the University of Michigan a Project Grant totaling $284,108 under the Aging Research program (CFDA 93.866), with an award period from January 1, 2026, through December 31, 2027. This research initiative delivers scientific investigation into how mechanical changes in the aging brain—specifically decreased stiffness and increased viscoelasticity—influence microglial function and contribute to...
- Federal Grant Award Summary The University of Michigan received a $2.99 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective September 1, 2025 through August 31, 2029. This research project investigates reactive oxygen species (ROS) as early-life modulators of longevity and examines the molecular mechanisms underlying aging and age-related diseases, including Alzheimer's and Parkinson's disease. The research leverages findings...
- This $715,500 federal Project Grant awarded by the National Science Foundation's (NSF) Engineering program will support research at the University of Illinois to investigate the relationship between exercise and cognitive health. The project aims to determine how muscle contraction during exercise may influence the activity and growth of cells in the hippocampus, the part of the brain involved in memory and learning. The research will conduct in vitro experiments culturing mouse muscle and...
- The University of California, San Diego will receive $400,000 from the National Science Foundation under the Engineering (CFDA 47.041) federal grant program to research the mechanisms of microgravity accelerated aging on human brain organoids from October 1, 2021 to September 30, 2024. Through this three-year Project Grant, UCSD researchers will study how microgravity exposure impacts the aging process in miniaturized human brain tissues grown in a laboratory, with the goal of furthering...
- The Trustees of Princeton University, Office of Research and Project Administration, received a $340,033 project grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems under the NSF Engineering directorate program (CFDA 47.041). The project, titled "ISS: The Influence of Microgravity on Bacterial Transport and Pellicle Morphogenesis," investigates the formation and growth of pellicles - bacterial communities that...
The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $399,146 Project Grant to the Regents of the University of Michigan under the Engineering program (CFDA 47.041) to develop a bioreactor system for conducting research on the effects of microgravity and aging on neuromuscular function. The objectives are to evaluate force generation and reactive oxygen species production in tissue-engineered human nerve-muscle constructs, analyze neuromuscular junction structure and gene expression profiles, and identify potential interventions to maintain neuromuscular function in aging and spaceflight. This research aims to provide new insights into the mechanisms behind age-related muscle loss and weakness, which could lead to the development of innovative therapies to improve physical frailty in the elderly. The grant period runs from October 1, 2023 through September 30, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $399.1k | 8/30/23 |