This $462,332 National Science Foundation project grant supports research into biomechanical regulation of intranuclear elastography and gene location in single cells. The NSF Division of Civil, Mechanical, and Manufacturing Innovation awarded this funding through the Engineering program (CFDA 47.041) to The Regents of the University of Colorado on September 1, 2022 for completion by August 31, 2025. The University of Colorado will conduct fundamental research measuring gene expression and...
This $382,124 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research to study the effects of microgravity on vascular health and cellular functions. The award recipient, Micro-Grx, Inc., will partner with the University of Florida, Ronawk, and Redwire to develop 3D "bio-block" tissue culture platforms that mimic vascular structures. These platforms will be used to grow cardiac and skin organoids and analyze the...
The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $399,146 Project Grant to the Regents of the University of Michigan under the Engineering program (CFDA 47.041) to develop a bioreactor system for conducting research on the effects of microgravity and aging on neuromuscular function. The objectives are to evaluate force generation and reactive oxygen species production in tissue-engineered human nerve-muscle constructs,...
This National Science Foundation (NSF) Engineering program (CFDA 47.041) Project Grant award of $320,000 to Rensselaer Polytechnic Institute (RPI) supports collaborative research on the microgravity effects of directional solidification and particle self-assembly. The research aims to reveal the subtle physical forces involved in crystal growth and particle assembly when solutions are frozen in the absence of gravity, compared to Earth-based conditions. The findings will inform the design of new...
This $449,582 National Science Foundation project grant funds research at Virginia Polytechnic Institute and State University from October 1, 2022 to September 30, 2025 under the NSF Engineering program (CFDA 47.041). The research aims to understand the effects of microgravity on wound healing processes by leveraging a sensor-integrated 3D tissue culture model. Specifically, the project will explore dynamic changes in gene and protein expression, structural changes in capillary network formation...
This National Science Foundation (NSF) Project Grant award under CFDA 47.041 (Engineering) provides $600,000 in funding to Embry-Riddle Aeronautical University, Inc. to conduct research on leveraging light-matter interactions to create new functional sensors for use in low-gravity space environments. The key objectives of this 3-year project are to investigate the effects of microgravity on the processing and properties of ceramic nanocomposite materials, and to utilize this understanding to...
This federal Project Grant award of $400,000 from the National Science Foundation's (NSF) Division of Civil, Mechanical, and Manufacturing Innovation (CFDA 47.041 - Engineering) supports research to study the effects of microgravity on cancer-myeloid organoids, which are 3D models that mimic the brain tumor microenvironment. The research aims to reveal novel cellular and molecular mechanisms underlying the relationship between immune cells and mechanical forces in glioblastoma, the deadliest...
This $350,000 National Science Foundation project grant supports research at the University of Virginia from October 1, 2022 to September 30, 2025 under the NSF Engineering program (CFDA 47.041). The research aims to advance understanding of the effects of microgravity on wound healing processes by leveraging a sensor-integrated 3D tissue culture model. Specifically, the project will explore dynamic changes in gene and protein expression, endothelial network formation, and extracellular matrix...
This $616,151 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The research aims to improve the understanding of how tissues form, how embryos develop, and how diseases progress, with potential implications for advancements in tissue engineering and medicine. The 3-year project, set...
The National Science Foundation awarded a $399,685 project grant to the University of California Irvine under the Engineering program (CFDA 47.041) to develop innovative cartilage tissue engineering strategies utilizing the microgravity environment of the International Space Station. The objectives of the three-year award beginning September 1, 2022 include employing microgravity conditions to enhance key processes in earth-based cartilage tissue engineering such as redifferentiation of expanded...