The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded the University of Florida (UF) a $750,000 Project Grant under the Biological Sciences program (CFDA 47.074) to investigate the mechanism of superinfection exclusion (SIE) by Citrus Tristeza Virus (CTV), a plant virus model system. The project aims to elucidate the role of a viral long non-coding RNA in the SIE phenomenon, which influences viral pathogenesis and evolution. Key research activities include utilizing advanced molecular biology, microscopy, biochemistry, and genetic tools to further the understanding of viral SIE, interactions between virus variants in a host, and the functions of viral long non-coding RNAs in SIE and virus-host interactions. The project provides research opportunities for students, including underrepresented groups, and the results will be disseminated through publications and scientific conferences. The award supports this foundational research from Sep 1, 2023, to Aug 31, 2026.
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