The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded a $299,990 Project Grant to Worcester Polytechnic Institute to investigate how tissue stiffness and fluid flow coordinate to regulate lymphatic capillary growth and function. This two-year award, issued on February 1, 2022 with a completion date of January 31, 2024, falls under the NSF Directorate for Engineering's CFDA #47.041 Engineering program. The program seeks to improve quality of life...
This $635,000 Project Grant awarded by the National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation supports research to understand how mechanical boundary conditions influence tissue assembly and repair in 3D fibrous microtissues. The research aims to advance knowledge about the mechanisms by which mechanical forces regulate new tissue formation and organization, particularly as it relates to wound healing. The project will integrate in vitro experiments and...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) seeks to improve the design and safety evaluation of Nitinol medical devices through the development of a specialized multiscale computational modeling approach using artificial intelligence (AI). The $200,000 award, effective September 1, 2024 through August 31, 2026, will be executed by the Regents of the University of Minnesota. The research aims to create a validated modeling method that...
The University of California, Merced received a $200,000 Project Grant award from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation on May 15, 2022 to support research under the Engineering program (CFDA 47.041). The award will fund research from May 15, 2022 through April 30, 2024 to develop multi-scale models of cell-matrix mechanical interactions during endothelial cell network assembly. The Engineering program seeks to improve quality of life and...
This $487,795 award from the National Science Foundation (NSF) Engineering grant program (CFDA 47.041) supports Arizona State University in developing innovative ex vivo models of the tumor microenvironment (TME). The project aims to mechanistically understand how biophysical cues and signaling between stromal and immune cells contribute to the transition of tumor cells into an invasive phenotype, as well as explore how stromal cell function induces pathway signatures in tumor cells leading to...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
This $823,472 National Science Foundation project grant will fund research at the University of Wisconsin-Madison to advance understanding of soft tissue interfaces. The Division of Civil, Mechanical, and Manufacturing Innovation is supporting this work under the Engineering program (CFDA 47.041). The university researchers will experimentally and computationally investigate the mechanisms governing the mechanical behavior of soft tissue interfaces. They will conduct experiments to quantify...
This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $599,998 in funding to the Regents of the University of Michigan from July 1, 2025 to June 30, 2030. The project, titled "CAREER: Topography-Mediated Immunomodulation for Implant-Associated Infections", aims to study how the physical properties of biomaterial surfaces, particularly nano- and micro-scale patterns, affect interactions between immune cells and pathogens. The research...
This National Science Foundation (NSF) Faculty Early Career Development (CAREER) award, funded under the NSF Engineering program (CFDA 47.041), will support $646,451 in research over 5 years to study how the mechanical properties of tissue extracellular matrices regulate neutrophil function, which is crucial for infection clearing, wound healing, and disease fighting. The research will utilize engineered collagen-alginate hydrogels and a microfluidic "inflammation-on-a-chip" device...
This National Science Foundation (NSF) Division of Materials Research Project Grant, CFDA# 47.049 Mathematical and Physical Sciences, provides $400,000 in funding to The Trustees of the University of Pennsylvania to conduct collaborative research on developing novel hybrid metal-piezoelectric biomaterials for anti-infectious implantable medical devices. The key objective is to create advanced multifunctional biomaterial platforms that can effectively prevent biofilm formation and bacterial...