The National Science Foundation (NSF) has awarded a $360,000 Project Grant under the CFDA Program "Computer and Information Science and Engineering" to the University of Texas at Austin (UT Austin) and Michigan State University for a collaborative research project. The goal of this 4-year project is to develop a novel framework for continuous, precise, and closed-loop control of bi-hormone (insulin or glucagon) secretion from genetically modified islet organoid grafts using tiny,...
This $800,000 National Science Foundation project grant supports the development of label-free microscopy systems and algorithms for functional imaging and continuous monitoring of insulin granules in live pancreatic islets. Funded under the NSF Engineering program (CFDA 47.041), the three-year award to Beth Israel Deaconess Medical Center aims to advance understanding of diabetes through non-invasive study of insulin secretion dynamics. Specifically, the grantee will combine novel confocal...
The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $450,000 Project Grant to the Texas A&M Engineering Experiment Station (Tees) to develop an injectable, grain-of-rice size glucose biosensor for continuous blood sugar monitoring. The key products or services to be provided under this 3-year grant include: Developing an injectable glucose biosensor comprised of a self-cleaning membrane and a near-infrared fluorescence...
The National Science Foundation (NSF) awarded a three-year, $449,999 Project Grant under their Engineering program (CFDA 47.041) to the University of Cincinnati to develop an implantable biosensor platform that can continuously monitor various biomarkers in the body for over a year. The project aims to create a new class of long-lasting aptamer-based sensors protected by robust porous oxide coatings, which would enable the first practical implantable monitoring system for managing chronic...
This $241,823 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports the development of an implantable engineered tissue with optogenetically engineered human beta-cells. The project aims to address challenges in creating vascularized tissues with light-activatable cells to improve treatment for diabetes. Key activities include designing a gelatin-based engineered tissue with oxygen-generating microparticles and optogenetically...
This Project Grant award of $599,918 from the National Science Foundation (NSF) Engineering program (CFDA 47.041) to the Massachusetts Institute of Technology (MIT) aims to develop a novel, non-surgical bioelectronic brain implant for targeted neural stimulation. The proposed technology seeks to enable precise, high-resolution brain stimulation without the need for invasive surgery by leveraging advanced physics, electrical engineering, and synthetic biology innovations. This paradigm-shifting...
This $260,609 Project Grant from the National Science Foundation Division of Electrical, Communications and Cyber Systems will support the development of multi-channel, sub-microliter implants for selective neuromodulation at Boise State University from September 1, 2023 through August 31, 2028. The grant is jointly funded through NSF's Engineering Directorate and Established Program to Stimulate Competitive Research, both of which aim to advance innovation in engineering research. Under this...
The National Science Foundation awarded Boise State University a $199,999 project grant under the Engineering program (CFDA 47.041) to develop microscale neural implants for closed-loop neuromodulation from March 2022 through February 2024. The university will advance bioelectronic medicine miniaturization to enable simultaneous neural sensing and stimulation for personalized closed-loop therapy. Key activities include developing a cross-domain simulation framework to optimize microscale...
This Project Grant award from the National Science Foundation's (NSF) Engineering program provides $150,000 to Baylor University to conduct collaborative research on large-scale wireless RF networks of microchip sensors. The key objectives are to: 1) build a microsensor system and demonstrate low-error rate and efficient asynchronous, encoded wireless transmission in the laboratory using fabricated microchips, and 2) decode signals from a hypothetical brain implant composed of up to 8,000...
This National Science Foundation (NSF) Project Grant award, under the Mathematical and Physical Sciences program (CFDA 47.049), provides $432,000.00 to Arizona State University (ASU) to develop a framework for creating personalized digital twins of human physiology using first-principles modeling and machine learning. The research aims to integrate real-world patient data, particularly from those with type 1 diabetes, into virtual representations that can aid in the development and evaluation of...
This National Science Foundation (NSF) Division of Computer and Network Systems Project Grant award totaling $839,998 to Michigan State University supports the development of a novel wireless optoelectronic implant system for closed-loop control of bi-hormone (insulin and glucagon) secretion from genetically modified islet organoids. The goal is to create an implantable, wireless, and battery-free device that can precisely regulate hormone levels to manage type 1 diabetes. The project involves collaborators at the University of Texas at Austin and will integrate optical stimulators, glucose sensors, and wireless communication into a compact implant. This multidisciplinary research in biomedical devices, stem cell biology, and wireless microelectronics is expected to lead to transformative personalized therapies for type 1 diabetes and have broader societal impacts through educational and outreach initiatives. The award period runs from August 1, 2023 to July 31, 2027.