The $209,101 National Science Foundation award under the Mathematical and Physical Sciences program (CFDA 47.049) funds a collaborative research project between North Carolina State University and the University of Miami from September 1, 2023 through August 31, 2026. The project aims to develop a new class of synthetic dyes with photoactivatable fluorescence for bioimaging applications through the synthesis, characterization, and single-molecule spectroscopic analysis of four series of...
This National Science Foundation (NSF) Project Grant award under the Mathematical and Physical Sciences program (CFDA 47.049) provides $641,448 to North Carolina State University (NC State) for a 5-year project titled "Understanding and Controlling Single-Molecule Fluorescence Spectral Heterogeneity of Organic Fluorophores". The project, led by Professor Yang Zhang, aims to advance the understanding of chemical mechanisms underlying the variability in fluorescence spectra of single dye...
This Project Grant from the National Science Foundation Division of Chemistry, titled "SYNTHESIS, PROPERTIES AND DYNAMICS OF BODIPY-BASED FLUOROPHORES," provides $470,000 in funding from September 1, 2021 to August 31, 2024. The award supports work under the Mathematical and Physical Sciences program (CFDA 47.049) to advance the progress of these sciences and strengthen the Nation's scientific enterprise through increased knowledge and understanding of major problems. Specifically, the...
This Project Grant award of $600,000 from the National Science Foundation's (NSF) Mathematical and Physical Sciences program, Grant No. 47.049, supports research by Professor Lei Zhu of the Department of Chemistry and Biochemistry at Florida State University. The goal is to understand the factors, both structural and environmental, that control the photophysical and photochemical properties of two categories of organic fluorescent dyes. The first category will have the capability of excited...
The National Science Foundation (NSF) awarded a $437,749 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of North Carolina at Charlotte. The grant supports a research project to investigate a new class of luminescent protein materials and their potential applications in imaging, sensing, and biological tracking. The project aims to characterize the chemical and physical properties of known luminescent protein-metal compounds, and leverage...
This National Science Foundation (NSF) Project Grant, awarded under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), provides $587,497 to Louisiana State University (LSU) and Appalachian State University to develop new fluorescent dyes called BORon DIpyrrole methenes (BoDIPYs) for use in biology and materials science. The key aims are to: 1) Design and synthesize new fluorinated BODIPY dyes and derivatives, 2) Investigate their photophysical and chemical properties,...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) in the amount of $364,969 will fund the development of a toolbox of switchable and functional fluorescent probes for multi-functional super-resolution microscopy (MF-SRM). The overarching goal is to enable new experimental and computational studies in the fields of chromatin epigenetics and spatially-resolved multi-omics by decoding...
This National Science Foundation Project Grant provides $330,000 to the University of Miami from July 2022 through June 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). Professors Marc Knecht of the University of Miami and Anatoly Frenkel of Stony Brook University will collaborate to design functional biomolecular interfaces for multifunctional nanomaterials. They will synthesize specially designed peptides to bind to and present unique chemical activities on the surfaces...
This Project Grant award from the National Science Foundation's (CFDA 47.049 - Mathematical and Physical Sciences) provides $605,020 to Professor Byron Purse of the Department of Chemistry and Biochemistry at San Diego State University to study the design and properties of fluorescent nucleobase analogues (FBAs). The research aims to investigate the mechanisms of fluorescence turn-on in response to base pairing and stacking, improve the photostability of pyrimidine analogue FBAs, and explore...
The National Science Foundation (NSF) awarded a 5-year, $430,413 CAREER grant to Wayne State University for a project titled "COMPUTATIONAL DESIGN OF FLUORESCENT PROTEINS WITH MULTISCALE EXCITED STATE QM/MM METHODS." The project, funded under NSF's Mathematical and Physical Sciences (CFDA 47.049) program, aims to advance the understanding and rational design of new fluorescent protein sensors. The research will use classical molecular dynamics, excited state quantum...