This National Science Foundation award provides $584,997 to the University of California, Los Angeles under the Biological Sciences federal grant program (CFDA 47.074) from May 1, 2023 through April 30, 2026. The funding supports collaborative research exploring the potential roles of non-coding RNAs in encoding memory. Specifically, the award will examine whether behavioral sensitization memory can be stored by non-coding RNA or induce downstream molecular changes that store memory in the...
This National Science Foundation project grant award of $220,000 supports research into RNA-encoded molecular memory at The Trustees of Mount Holyoke College from May 1, 2023 through April 30, 2026. The research will explore the potential roles of non-coding RNAs in encoding memory, building on prior evidence that some forms of simple memory may be stored as changes in RNA molecules. The principal investigators and their team will conduct differential RNA sequencing on trained and untrained...
This National Science Foundation project grant award of $600,000 supports research into the mechanisms underlying long-term memory storage at the University of California, Los Angeles from February 1, 2022 to January 31, 2025. The award is made under the Biological Sciences program (CFDA 47.074) to promote progress in the biological sciences. Specifically, the grant funds research investigating whether memories are stored through nuclear modifications in neurons rather than changes in...
The National Science Foundation (NSF) awarded a $300,000 Project Grant under its Biological Sciences program (CFDA 47.074) to the Georgia TECH Research Corporation for the "TOOLS4CELLS: EAGER: A MOLECULAR PURSUIT FOR THE ENGRAM: MICROFLUIDIC TEMPORAL TRANSCRIPTOMICS FOR SINGLE CELL LEARNING" project. This 2-year effort aims to develop innovative microfluidic tools and workflows to investigate the role of non-coding RNA in learning and memory storage in single-celled organisms. Key...
This $2.11 million project grant from the National Science Foundation's Division of Emerging Frontiers, under the Biological Sciences federal grant program (CFDA 47.074), will fund research at Emory University and the University of Tennessee from March 2023 through February 2027 to rationally design long noncoding RNAs (lncRNAs) for epigenetic signal amplification. The researchers will define the minimal features required for large-scale silencing mediated by lncRNAs, building on the...
This $578,632 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, funds research to investigate the mechanisms of neuronal activity-induced gene expression and epigenetic memory. The primary grantee, the University of Texas Southwestern Medical Center, will study how chromatin regulators, particularly the BRG1 protein, control the priming...
The National Science Foundation (NSF) awarded a $1,199,997 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Colorado-Denver. The grant will fund research to improve understanding of the mechanisms underlying messenger RNA (mRNA) localization and translation, and develop machine learning models to better predict protein production from mRNA. The project will apply recent advancements in RNA sequencing technology to study how factors like tRNA abundance and...
This $660,000 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at the University of Southern California (USC) on how RNA editing regulates synaptic plasticity and behavioral adaptations in the fruit fly Drosophila melanogaster. The project aims to investigate how RNA editing of glutamate-gated chloride and voltage-gated calcium channels impacts neural circuit function, synaptic plasticity, and organismal behaviors....
This Project Grant from the Department of Health and Human Services National Institutes of Health Office of the Director, under the Trans-NIH Research Support program (CFDA 93.310), provides $2,855,400 to Baylor College of Medicine for a research project titled "Uncovering Brain-Wide Molecular Determinants of Individual Memory Performance Across Lifespan." Over a three-year period from September 15, 2022 to August 31, 2025, the grantee will use the invertebrate model C. elegans to...
This $900,000 project grant awarded by the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research to understand the molecular mechanisms by which the DNA methyltransferase enzyme DNMT1 regulates gene silencing and the inheritance of cell identity. The project will utilize structural biology, biochemistry, and cell biology methods to investigate how DNMT1 activity is regulated by interactions with RNA and chromatin modifications. This work aims to...