Project Grant 2243536
- This $796,460 project grant from the National Science Foundation's Division of Integrative Organismal Systems and Biological Sciences program will fund research into the role of extracellular RNA in intercellular and interkingdom communication. The University of South Alabama will lead a collaborative effort between seven laboratories to advance understanding of how RNA secreted by host cells maintains healthy microbiomes in plants, insects, and humans. The researchers will test the hypothesis...
- This Project Grant from the National Science Foundation's Division of Integrative Organismal Systems and Plant Genome Research Program and Plant Biotic Interactions Program, totaling $856,318, will fund research from March 1, 2023 to February 28, 2027. The grant supports a collaborative project between seven laboratories to further understanding of the role of extracellular RNA (exRNA) in intercellular and interkingdom communication. Specifically, the researchers aim to test the hypothesis...
- This four-year, $822,736 project grant from the National Science Foundation's Division of Integrative Organismal Systems and Biological Sciences program will fund research into the role of extracellular RNA in intercellular and interkingdom communication. Led by Clemson University, the collaborative project brings together seven laboratories to advance understanding of how RNA secreted by host cells maintains healthy microbiomes in plants, insects, and humans. The researchers will investigate...
- This $805,832 project grant from the National Science Foundation's Division of Integrative Organismal Systems, under the Biological Sciences (CFDA 47.074) federal grant program, will fund research into the role of extracellular RNA in intercellular and interkingdom communication. A collaborative team of seven laboratories will investigate how RNA secreted by host cells influences microbiome health and composition in human gut, insect gut, and leaf surface models. Specifically, the researchers...
- This National Science Foundation project grant of $771,071 awarded on March 1, 2023 will fund research into the role of extracellular RNA (exRNA) in intercellular and interkingdom communication through February 28, 2027. The award is part of the Biological Sciences program under the CFDA number 47.074, which supports basic biological research to strengthen the Nation's scientific enterprise and increase knowledge of major problems. Specifically, a collaborative team of seven laboratories at...
- The National Science Foundation (NSF) awarded a $919,999 Project Grant under the Biological Sciences program (CFDA 47.074) to the Regents of the University of California at Riverside. This 3-year grant, beginning September 1, 2023, supports research to investigate the evolution and functional role of small regulatory RNAs (sRNAs) in diverse bacterial lineages, particularly those living symbiotically within pest insect hosts. The project aims to determine how sRNA sequence divergence and...
- This $849,713 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to elucidate RNA-RNA interaction networks during interbacterial interactions involving the bacterium Pseudomonas aeruginosa. The research team at Boston Children's Hospital seeks to define the small RNA (sRNA) interaction network in P. aeruginosa and decode the regulatory roles played by sRNAs during its interactions with other bacteria. The project will...
- This NSF Biological Sciences (CFDA 47.074) Project Grant award of $600,000 to Emory University will investigate how microbiome communities, which are communities of bacteria and other microbes that live in and on organisms, can resist change and transition to alternate states. The project will use the nematode worm Caenorhabditis elegans as a model host to better define the stability and properties of alternate microbiome states, as well as how factors like antibiotic treatment and host...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program has awarded a $357,385 project grant to the University of Texas at Arlington (UTA) to uncover the mechanistic interactions between RNA interference (RNAi) and chromatin modifying pathways that regulate gene expression during cellular stress. Using the C. elegans germline as a model system, the research project will employ interdisciplinary approaches including genetics, physiological assays,...
- This three-year, five-hundred twenty-three thousand four-hundred sixty-one dollar project grant from the National Science Foundation's Division of Molecular and Cellular Biosciences will fund research into RNA processing in trypanosome mitochondria. The grant was awarded to Seattle Children's Research Institute on April 1, 2022 and will be completed by March 31, 2025. The project aims to advance understanding of gene expression regulation in trypanosomes, single-celled parasites that alternate...
This four-year, $924,987 project grant from the National Science Foundation's Division of Integrative Organismal Systems and Directorate for Biological Sciences will fund research into the role of extracellular RNA (exRNA) in intercellular and interkingdom communication. Specifically, the collaborative project between seven laboratories will examine the hypothesis that RNA secreted by host cells plays a key role in maintaining microbiome and overall health through cell-to-cell communication and microbiome composition modification. The researchers will study exRNA selection for secretion and uptake both within and between species using human gut, insect gut and plant leaf surface models. They will also assess the impact of exRNA on microbiome health. This work aligns with the Biological Sciences program's goal of increasing biological knowledge to address national challenges. Results from this research could enable manipulation of exRNA communication in agriculture and medicine to develop environmentally-friendly pesticides and microbiome-focused health treatments.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $925.0k | 3/7/23 |