This Project Grant award from the National Science Foundation's Division of Information and Intelligent Systems (CFDA 47.070 - Computer and Information Science and Engineering) aims to develop a cyber-physical system that uses microrobots to control and direct the differentiation of genetically engineered stem cells to form desired pancreatic tissue. The $499,181 project, which will run from September 1, 2023 to August 31, 2026, focuses on overcoming the challenge of recreating the complex 3D spatial patterns found in human pancreatic tissue using current tissue engineering approaches. By leveraging a "robot-in-the-loop" approach, the research team seeks to provide spatiotemporal precision and feedback control to guide cell behavior and enable the scalable production of human pancreatic organoids. This innovative technology has the potential to serve as a bridge between preclinical and clinical trials, improving drug testing models and advancing personalized medicine. The University of Delaware is the sole awardee on this project and does not plan to issue any subawards.