This National Science Foundation Project Grant award of $1,324,710 provides funding from July 1, 2022 through June 30, 2025 to support research understanding how newly evolved genes acquire protein interactions and regulatory mechanisms in Drosophila reproduction. Funded under the Biological Sciences program (CFDA 47.074), the award to the College of the Holy Cross will explore how three genes essential for Drosophila melanogaster spermatogenesis evolved novel capabilities, including physical...
This $240,000 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) funds a postdoctoral research fellowship to investigate the role of genome organization on de novo gene origination. The research aims to test a new theoretical model explaining the process of new gene evolution, by examining how the genome's structural features influence the birth of genes that arise from non-coding regions. The key components of the research include: 1)...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $240,000 provides funding for a postdoctoral research fellowship focused on modeling gene drive with selfish germline stem cells in the Drosophila testis. The key products and services to be delivered through this 3-year project include: Identification of Chinmo protein binding sites on chromatin and Chinmo transcriptional targets in germline stem cells (GSCs) using CUT&RUN and...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $500,176 to Eastern Michigan University (EMU) will advance fundamental understanding of the molecular mechanisms regulating gene expression. The 3-year project will study the structure and function of the UHRF1 and UHRF2 epigenetic regulator proteins, which play critical roles in processes like cell cycle control and DNA repair. The research aims to elucidate differences in histone binding...
This $120,227 project grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program supports research at Northeastern University to develop a new theoretical approach for studying the three-dimensional architecture and conformational ensembles of genes and gene clusters. The project aims to: (i) model the mechanics of chromatin at the gene scale, (ii) investigate how genomic conformations are affected by factors like supercoiling and...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $240,000 provides funding for a postdoctoral research fellowship from July 1, 2024 to June 30, 2027. The fellowship will support research and training to investigate the rules governing interactions between genomes, environment, and phenotypes, with a focus on understanding how repetitive DNA sequences, particularly a satellite repeat on the X chromosome of Drosophila melanogaster, influence...
This $452,399 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Hofstra University to investigate the epigenetic regulation of transposable elements in maize. The research aims to study the RNA-directed DNA methylation (RDDM) induced by naturally occurring maize "killer" alleles and explore the dynamic regulation of transposable element silencing in response to developmental cues. The project will...
This National Science Foundation (NSF) project grant, awarded under the Biological Sciences program (CFDA 47.074), will support research to investigate the mechanisms of developmental plasticity and how maternal metabolic state can influence embryo development and offspring traits in fruit flies. The $950,000 award to the Van Andel Research Institute (VAI) in Grand Rapids, Michigan will enable the researchers to generate an integrated dataset on the transcriptomic and metabolic changes triggered...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $2,720,800 in funding to Brigham & Women's Hospital Inc. to conduct research on the epigenetic regulation of transcriptional programming. The research will focus on understanding the dynamic competition between Polycomb (PcG) and Trithorax Group (TrxG) proteins, and how this impacts cell type-specific...
This National Science Foundation project grant of $502,553 will fund research at the University of North Dakota from April 2023 through March 2026 under the Biological Sciences federal grant program (CFDA 47.074). The research will study molecular mechanisms regulating the poly(ADP-ribosyl)ation pathway in living cells, using the fruit fly Drosophila as a model system. Specifically, the project will characterize molecular targeting and regulation of two key enzymes, PARP1 and PARG, that...