Project Grant 2231082
- This three-year, $647,113 National Science Foundation project grant supports research into evolving quantum mechanical tunnelling in enzymes. The award funds a collaborative effort between the University of Arizona and UK researchers to explore how quantum effects may be built into enzyme function using directed evolution techniques. The project will train pre- and post-doctoral students in interdisciplinary biosciences research methods while exposing them to international collaboration. It also...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (MPS) program provides $375,000 in funding to Purdue University to investigate entangled states in organic molecules and explore methods for generating high-fidelity quantum states of light. The research aims to enhance photon collection efficiency and zero-phonon line in organic molecules integrated into nanophotonic cavities and waveguides. Additionally, the project will focus on bringing...
- The National Science Foundation (NSF) awarded a $740,797 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to the Regents of the University of California, San Francisco (UCSF) to develop and test new methodologies for the rational design of minimalistic light-switchable single-domain proteins. The goal is to engineer these proteins to bind specifically to target proteins in only one photoswitchable chromophore state, allowing for precise spatial and temporal control...
- The National Science Foundation awarded a $270,000 Project Grant under the Integrative Activities program (CFDA 47.083) to the University of New Mexico to develop an advanced optical microscopy system with unprecedented spatial and temporal precision. The research aims to dramatically improve the study of protein clustering and interactions on living cell membranes, which is crucial for understanding cell signaling processes and their relation to diseases like cancer. The highly...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $710,128 Project Grant under the Biological Sciences (CFDA 47.074) program to The Research Foundation For The State University Of New York (SUNY) to conduct collaborative research on the "Energy Landscapes of Designed Cold Unfolding Proteins." The research aims to enhance understanding of the distinct three-dimensional shapes that proteins can adopt at extreme cold temperatures and high...
- This National Science Foundation project grant award of $277,074 provides funding over three years from September 2022 through August 2025 under the Mathematical and Physical Sciences program (CFDA 47.049) to support collaborative research between the University of Connecticut and Michigan State University. The researchers will investigate the photophysical mechanisms by which the orange carotenoid protein in cyanobacteria converts between resting and active states in response to light...
- The National Science Foundation (NSF) has awarded a $400,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the Massachusetts Institute of Technology (MIT) for a collaborative research project on "Designing Coherence and Entanglement in Perovskite Quantum Dot Assemblies." This 4-year project aims to understand how perovskite quantum dots can be engineered to enable efficient and coherent transport of information and energy in a wave-like manner. The...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded Furman University a $594,094 Project Grant under the Biological Sciences program (CFDA 47.074) from July 1, 2022 to June 30, 2024. The grant will support research aiming to understand the roles of magnetoreception in avian navigation and develop methodology to measure magnetic field effects on chemical reactions occurring in photoreceptor molecules, with the goal of providing evidence that avian...
- This is a National Science Foundation (NSF) Project Grant award under the Mathematical and Physical Sciences grant program (CFDA 47.049) totaling $799,915. The project, titled "EXPANDQISE: TRACK 1: INTEGRATING SINGLE MOLECULES TO TWO-DIMENSIONAL MATERIALS TOWARD QUANTUM DEVICES," aims to develop scalable and controllable single-molecule field effect transistors using advanced 2D materials and atomic force microscopy nanolithography techniques. The overarching goal is to create...
- This Project Grant award from the National Science Foundation provides $300,000 to Dr. Pablo Unzueta of Stanford University under the Mathematical and Physical Sciences program (CFDA 47.049). The funding supports research into elucidating the design rules of Green Fluorescent Protein using quantum mechanical modeling and machine learning techniques. Dr. Unzueta will collaborate with experimentalists and apply ab initio molecular dynamics simulations and a generative model incorporating refined...
COLLABORATIVE RESEARCH: MAPPING AND COMPARING THE LINK OF THE PROTEIN SCAFFOLD TO QUANTUM EVENTS IN THERMALLY ACTIVATED ENZYMES AND FLAVIN-BASED PHOTORECEPTORS -THIS PROJECT STUDIES HOW BIOLOGICAL MACROMOLECULES ARE ABLE TO EFFICIENTLY PROMOTE AND UTILIZE NON-TRIVIAL QUANTUM PHENOMENA AT OR NEAR ROOM TEMPERATURES THAT ARE NECESSARY FOR FUNCTION. THIS PROJECT WILL PROVIDE A NEW UNDERSTANDING FOR HOW BIOLOGY INTEGRATES QUANTUM BEHAVIOR INTO MACROMOLECULAR FUNCTION. THERE IS ALSO THE POTENTIAL TO INFORM AND AID THE ADVANCEMENT OF NEW QUANTUM SCIENCE AND TECHNOLOGIES, SUCH AS THE DEVELOPMENT OF DE NOVO SYSTEMS THAT HARNESS QUANTUM PHENOMENA. THIS PROJECT PUTS FORTH A HIGHLY COLLABORATIVE, SYNERGISTIC RESEARCH APPROACH ENTAILING A MULTI-DISCIPLINARY STUDY IN STRUCTURAL BIOLOGY, PROTEIN BIOCHEMISTRY, ENZYMOLOGY, CHEMISTRY, AND PHYSICS. MENTORSHIP IS KEY TO THE SUCCESS OF THIS PROJECT WITH MULTI-LAYERED TRAINING OPPORTUNITIES, BUILT ON THE PRINCIPLES OF ?TEAM SCIENCE?, AVAILABLE TO POSTDOCTORAL TRAINEES AS WELL AS GRADUATE AND UNDERGRADUATE STUDENTS. THE PROJECT WILL ALSO DEVELOP AN INNOVATIVE, CROSS-INSTITUTIONAL, COURSE-BASED RESEARCH EXPERIENCE TO BE IMPLEMENTED IN THE UNDERGRADUATE CURRICULUM. THIS EFFORT WILL BE AIMED AT BIOLOGY-FOCUSED AND PRIMARILY UNDERREPRESENTED STUDENTS WHO WILL BE ENGAGED IN RESEARCH THAT IS RELATED TO NON-TRIVIAL QUANTUM EFFECTS IN BIOLOGY. PROTEINS, AND POSSIBLY OTHER MACROMOLECULES, HAVE EVOLVED IN A MANNER TO INITIATE, SUSTAIN, ENHANCE, AND/OR COMMUNICATE QUANTUM PHENOMENA, INCLUDING TUNNELING AND SPIN COHERENCE. A FULL MECHANISTIC UNDERSTANDING INTO HOW NATURE ACCOMPLISHES THESE INTERACTIONS, AND HOW IT LEADS TO A BIOLOGICAL OUTCOME, RESIDES IN THE SUCCESSFUL INTERPLAY BETWEEN THE SCAFFOLD OF THE PROTEIN AND ACTIVE SITE QUANTUM BEHAVIOR. INVESTIGATIONS WITHIN THIS PROJECT WILL DRAW ON CUTTING EDGE ADVANCES IN EXPERIMENTATION, INCLUDING TIME-RESOLVED AND TEMPERATURE-DEPENDENT STRUCTURAL STUDIES COUPLED WITH FUNCTIONAL ASSAYS, AND THEORY TO CREATE A COMPLEMENTARY AND HOLISTIC DATA-DRIVEN UNDERSTANDING OF THE RELATIONSHIP BETWEEN ENERGY FLOW IN A PROTEIN STRUCTURE AND EITHER THERMAL OR LIGHT INITIATION OF QUANTUM BEHAVIOR. THE RESEARCH FOCUSES ON TWO DISPARATE PROTEIN SYSTEMS WITH DISTINCT FOLDS AND COMPLEMENTARY QUANTUM EFFECTS ? HYDROGEN TUNNELING IN LIPOXYGENASE CATALYSIS AND SPIN COHERENCE IN CRYPTOCHROMES ASSOCIATED WITH MAGNETORECEPTION AND CIRCADIAN CLOCKS. THE UNDERLYING THEME OF THE RESEARCH WILL BE THE IDENTIFICATION AND MAPPING OF ANISOTROPIC PROTEIN NETWORKS THAT CONTROL VIBRATIONAL MOTIONS AND/OR CONFORMATIONAL CHANGES LINKED TO A PRODUCTIVE OUTPUT. THE PRINCIPLES THAT EMERGE FROM THIS RESEARCH GO BEYOND THE SCOPE OF HYDROGEN TUNNELING AND SPIN COHERENCE, BY EXPANDING OUR KNOWLEDGE BASE OF FUNCTION-COUPLED THERMAL AND LIGHT ACTIVATED PROTEIN NETWORKS. THE RESULTING INSIGHTS COULD POTENTIALLY BE LEVERAGED TO ENCODE NEW FUNCTIONALITIES INTO (RE)DESIGNED PROTEINS. THIS PROJECT IS SUPPORTED BY THE MOLECULAR BIOPHYSICS CLUSTER IN THE DIVISION OF MOLECULAR AND CELLULAR BIOSCIENCES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $92.2k | 7/24/25 | ||
| Not listed | $93.1k | 4/11/25 | ||
| Not listed | $199.3k | 3/27/23 |