This $300,000 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports the development of a new optical microscopy technology called "Space-Time-Pulsed Engineered-Excitation for Diffraction-Free Imaging (SPEEDI)." The technology utilizes exotic space-time wave packets to enable high-resolution fluorescence imaging of deep brain tissue without the light scrambling issues of conventional microscopy. The research aims to advance imaging...
The National Science Foundation (NSF) awarded a $299,999 Project Grant under the Engineering program (CFDA 47.041) to Mississippi State University (MSU). This 5-year "CAREER" grant, effective July 1, 2024, will fund research to develop a new method for detecting critical congenital heart defects (CCHDs) in newborns. The project aims to characterize and understand how chest vibrations measured by seismocardiography and gyrocardiography can serve as markers for detecting CCHDs, which can...
This Project Grant award, titled "CAREER: Integrated Multiphoton-Phase Microscopy for Simultaneous and Correlative Imaging of Neurovascular Coupling Dynamics," was provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041). The $583,679 award aims to develop an innovative microscopy system capable of simultaneously imaging various aspects of the brain to better understand the link between neurons and blood vessels. This will help advance the understanding...
This $400,000 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) to the University of Colorado aims to develop a new 3D label-free imaging technology called 3D Dynamic Contrast Optical Coherence Tomography (3D DYC-OCT). This advanced optical imaging system will enable high-speed, high-resolution 3D visualization of ciliary beating dynamics in human airway organoids, providing critical insights into airway cell function relevant to studying lung...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Macula Vision Systems Inc., a for-profit organization, supports the development of a novel microscopy platform to automate the interpretation of microbiology lab tests performed in hospitals. The project aims to address the shortage of trained lab technicians by engineering a specialized light source, customized camera, and AI-enabled algorithms to analyze...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $305,000 to Nanores LLC aims to develop a compact, multi-color super-resolution imaging system capable of visualizing molecular structures in thick biological tissues with nanoscale precision. The key products to be delivered include: An advanced fluorescence imaging system incorporating adaptive optics and spinning disk technology to enable 3D imaging of biological samples up...
This four-year, $708,333 National Science Foundation project grant funds research at Georgia Tech Research Corporation to develop genetic and microfluidic technologies to direct the differentiation of human induced pluripotent stem cell-derived retinal organoids. Specifically, the researchers will apply genome-wide methods leveraging both cell differentiation and biomechanical properties to screen for pathways that regulate retinogenesis. Systems biology approaches will identify master...
The Massachusetts Institute of Technology (MIT) has been awarded a 5-year, $487,873 National Science Foundation (NSF) Engineering Program (CFDA 47.041) Project Grant to develop advanced label-free microscopy technologies for deep-tissue biological imaging. The project aims to create innovative fiber optic light sources, excitation methods, and algorithmic reconstruction techniques to enable label-free multiplex imaging that can visualize dynamic cellular processes within living tissue with...
This $400,000 Project Grant award, provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), aims to develop a new label-free 3D imaging technology to study ciliary beating dynamics in human airway organoids. The technology, called 3D Dynamic Contrast Optical Coherence Tomography (3D DYC-OCT), will overcome limitations of current imaging methods by providing high-speed, high-resolution 3D visualization of cilia movement without the need for fluorescent labeling. This...
This $500,000 Project Grant award, provided by the National Science Foundation's Engineering program (CFDA 47.041), supports the development and validation of automated optoelectronic lab-on-a-chip platforms for comprehensive, real-time, multiparametric monitoring and control of live cell physiology. The research objectives include: 1) Exploring cellular-scale components for crosstalk-free electrical recording, stimulation, and fluorescence monitoring of in vitro live cell function; 2)...