Project Grant 2222345
- This Project Grant award of $410,977 from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) to Case Western Reserve University (CWRU) will fund research to develop methods for designing effective bacteriophage cocktails to precisely control the growth of unwanted bacteria in water systems. The key objectives are to: Identify genetic and transcriptomic markers of synergistic and antagonistic interactions between bacteriophages to guide the rational design of safe and...
- This Project Grant award of $427,625.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to exploit bacteriophages (viruses that infect bacteria) to discover novel anti-biofilm agents. The goal is to improve phage therapy and identify proteins that could be developed as stand-alone therapeutics to treat biofilm-associated infections, which are a particular concern for the opportunistic pathogen Pseudomonas aeruginosa....
- This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $240,000 will fund a 3-year postdoctoral fellowship to research the adaptive response of bacteria to bacteriophage infection and high hydrostatic pressure. The fellow will develop novel fluorescence microscopy techniques to quantify bacterial growth, cell size, and morphology under these environmental stressors using model organisms E. coli, P. aeruginosa, and S. piezotolerans. The project...
- This $300,000 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports a collaborative research project focused on understanding the mechanics and morphogenesis of bacterial biofilms. The award, with an effective date of December 1, 2025 and a completion date of November 30, 2028, will enable researchers at Yale University to conduct detailed observations and theoretical modeling of biofilm growth under varying environmental conditions, such as...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $273,652 to Phage Refinery LLC aims to develop a rapid and efficient parametric model for predicting the likelihood that a given bacteriophage (phage) will survive sufficiently long in the presence of an active immune system to be effective as a treatment against their target bacterial infection. The project will gather physical parameters and in-vivo persistence data for 400...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded a $479,999 Project Grant to The Johns Hopkins University to explore the interactions between CRISPR-Cas systems and temperate bacteriophages. The 5-year research project, starting on March 1, 2025, aims to investigate how CRISPR-Cas systems, which protect bacteria from viral infections, can exploit the life cycle of temperate phages to acquire new memories. The findings are expected to inform...
- This Project Grant award of $479,864 from the National Science Foundation's Engineering program (CFDA 47.041) supports the development of Synthetic Phages for Identifying and Enumerating Strains (SPIES) of bacterial pathogens. The project aims to re-engineer bacteriophages, viruses that naturally infect and kill bacteria, to serve as biosensors for the precise enumeration of pathogenic bacteria such as Shiga toxin-producing Escherichia coli. The SPIES technology will integrate synthetic gene...
- This federal Project Grant award of $1,000,000.00 from the National Science Foundation's Biological Sciences program (CFDA 47.074) was provided to The Trustees of Princeton University to study "Quorum Sensing Across Scales and Between Domains". The project aims to investigate bacterial communication processes, known as quorum sensing, to better understand how bacteria can synchronize behavior and potentially control harmful pathogens or promote beneficial bacteria. Key objectives...
- This Project Grant award from the National Science Foundation (CFDA 47.074 - Biological Sciences) provides $104,236.00 to support a team of undergraduate students from the University of Virginia in developing a low-cost, non-invasive, effective topical treatment for Staphylococcus-based cellulitis. The project aims to produce skin-penetrating antimicrobial peptides specific to Staphylococcus with the potential for scalable production. Through this effort, the students will receive hands-on...
- This $300,000 project grant, awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041), is focused on collaborative research to deepen the understanding of biofilm development and growth in constrained environments. The project aims to leverage highly tunable bacterial biofilm systems as a model to study the mechanics and morphogenesis of biological growth processes. Through a combination of confocal imaging, data analysis, and theoretical modeling, the...
This $200,000 National Science Foundation project grant under the Engineering program (CFDA 47.041) will support Colorado State University's development of phage-based biological drones to selectively target and destroy specific bacteria within biofilms. Over a two-year period from October 2022 to September 2024, the university will engineer minimal phage genomes that can deliver bacterial killing mechanisms only when a target bacterium such as Staphylococcus aureus is detected. The immediate goal is to demonstrate a phage drone's ability to kill S. aureus, with the long-term objective of creating a cocktail of engineered bacteria that can recognize and destroy multiple bacteria types within biofilms in environments like pipes, ships, food plants and healthcare settings. The grant will also provide training in phage and synthetic biology for undergraduate and graduate students, including members of underrepresented groups. This targeted approach could help reduce antibiotic resistance buildup within bacterial populations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $200.0k | 7/26/22 |