This National Science Foundation Project Grant award of $997,716 provides funding from May 15, 2022 through April 30, 2026 to investigate the molecular mechanisms that maintain the integrity of the bacterial cell envelope under stress conditions. The award was made under the Biological Sciences program (CFDA 47.074) to the Research Foundation of the City University of New York at the City College of New York.
Specifically, the awardee will examine how bacteria regulate the post-translational modification of lipoproteins when membrane homeostasis is altered by environmental or mutational stress. The research aims to provide fundamental insights into maintaining the fidelity of lipoprotein maturation in response to physicochemical changes in membrane properties. Experiments will probe the synthetic relationship between conserved bacterial genes linked to defective lipoprotein maturation. Findings are expected to enhance understanding of the molecular mechanisms that preserve bacterial cell envelope integrity when subjected to stressors.
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