This three-year, $101,452 Project Grant from the National Science Foundation's Mathematical and Physical Sciences program will support collaborative research between Old Dominion University and the College of William & Mary on the intrinsic gas-phase acid-base properties and structures of non-protein amino acids and peptides. The research teams, led by Drs. John and Jennifer Poutsma, will utilize mass spectrometry experiments and computational modeling to study how substituting...
This federal Project Grant award from the National Science Foundation (CFDA 47.074 Biological Sciences) provides $1,271,828 to Northeastern University and its sub-awardees, Tufts University School of Medicine and Tulane University, to develop new approaches for genetically engineering diverse strains of Clostridia bacteria. The research aims to overcome key limitations in Clostridial genetic manipulation, enabling accelerated study and control of their unique physiology and metabolism. The...
Old Dominion University Research Foundation was awarded a $383,637 Project Grant from the National Science Foundation Directorate for Mathematical and Physical Sciences under the Mathematical and Physical Sciences federal grant program (CFDA 47.049). The grant funds an undergraduate research opportunities program in chemistry for community college students at Old Dominion University from January 2022 through December 2024. The program aims to promote progress in the mathematical and physical...
This National Science Foundation project grant of $512,676 will fund research at Duke University from August 2022 to July 2025 under the Biological Sciences program (CFDA 47.074). The research aims to advance understanding of mechanosensitive channels in bacteria through single-molecule force spectroscopy experiments using an atomic force microscope. Investigators will observe the opening of individual mechanosensitive channels in living E. coli and B. subtilis bacteria in response to mechanical...
This $461,575 Project Grant awarded by the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research at Earlham College to investigate how the bacterial enzyme ProXP-X recognizes and binds to both L- and D-amino acids. The project aims to determine the specific mechanisms by which ProXP-X distinguishes between L- and D-amino acids, as well as how this enzyme protects bacterial cells from the toxicity of D-amino acids. The findings will advance the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $792,584 to Old Dominion University and its affiliated research foundation to develop multi-resolution docking methods and computational modeling tools for cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET). The 5-year project aims to advance flexible fitting and refinement of AlphaFold2 models, improve...
This Project Grant award of $222,000 from the National Science Foundation's (NSF) Mathematical and Physical Sciences (47.049 CFDA) program supports research at Bryant University to develop new chemical biology tools for studying peptidoglycan metabolism in bacteria. Led by Dr. Christopher Reid, the project aims to expand on the team's previous work with the inhibitor masarimycin to create an array of novel glycosyl triazole and diamide compounds that can probe the degradative steps of...
This $401,253 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program will support research at The Pennsylvania State University to elucidate novel cyclic nucleotide signaling pathways and physiological effects in bacteria. The 5-year program aims to synthesize chemical tools and use in vitro and in cellulo techniques to investigate the effects of 2',3'-cyclic nucleotide monophosphates (2',3'-cNMPs)...
This National Science Foundation (NSF) Project Grant award, funded under the Integrative Activities program (CFDA 47.083), supports research on the structural mechanisms of bacterial extracellular DNA-recognition. The $216,149 award to the Board of Regents of the University of Nebraska, from July 1, 2023 to June 30, 2026, aims to identify and characterize novel DNA receptor subunits incorporated into bacterial surface appendages. The project will purify soluble protein constructs, measure...
The National Science Foundation (NSF) awarded a $552,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the University of Nevada, Reno (UNR). The 3-year grant, starting on August 1, 2023, supports research led by Professor Tal-Gan to study the interplay between different bacterial communication pathways in Streptococcus mutans. The project aims to characterize how diverse quorum sensing circuits within the same bacterial species affect one another and...