This $1,200,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports the development and application of a time-resolved cryo-electron microscopy (cryo-EM) method to study the dynamics of diverse biological molecules. The principal investigator and their team at Columbia University will use newly designed PDMS-based microfluidic chips to rapidly mix and freeze biological samples, enabling the capture of intermediate conformational...
Cornell University was awarded a $1,000,000 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences to support research titled "Engineering Photosensory Proteins Through the Better Understanding and Control of Proton-Coupled Electron Transfer Reactions." The award period is from August 1, 2021 through July 31, 2025. The grant funding will support basic research conducted under the Biological Sciences program (CFDA 47.074) to advance...
This National Science Foundation Project Grant of $600,000 will support research at Cornell University from June 2022 through May 2024 under the Biological Sciences program (CFDA 47.074). The university will conduct cryogenic electron microscopy analysis of the chloroplast CLP protease system in Arabidopsis thaliana to determine the three-dimensional structure of the endogenous ~1,000 kDa CLP protease-chaperone complex. The research aims to unravel the structural details of this chloroplast...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant, awarded to Cornell University, aims to advance the understanding of how novel proteins give rise to novel traits, using the cnidarian stinging apparatus as a model system. The $230,000 award, effective from March 15, 2025 to February 28, 2030, will support research to characterize the protein-protein interactions necessary for the development of the cnidarian stinging apparatus, as well as investigate the...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $710,128 Project Grant under the Biological Sciences (CFDA 47.074) program to The Research Foundation For The State University Of New York (SUNY) to conduct collaborative research on the "Energy Landscapes of Designed Cold Unfolding Proteins." The research aims to enhance understanding of the distinct three-dimensional shapes that proteins can adopt at extreme cold temperatures and high...
This Project Grant award of $630,000 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will support the development of an advanced optical microscopy system at the University of New Mexico (UNM). The system will combine the MINFLUX and modal imaging techniques to enable high-speed (kHz rates) tracking and near-quantum optimal measurement of the separation between fluorophore-tagged proteins on living cell membranes. This unprecedented spatiotemporal...
This federal Project Grant award of $100,000 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports collaborative research to develop deep learning-based "consistency models" that can simulate the long-time dynamics of protein structures more efficiently than traditional molecular dynamics simulations. The research aims to overcome limitations in capturing millisecond-scale protein behavior, which is crucial for understanding processes like...
This $100,000 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports the development of deep learning-based computational models to simulate long-duration protein dynamics more efficiently than traditional molecular dynamics simulations. The research, conducted by the University of Missouri System, aims to create "consistency models" that can predict probabilistic distributions of molecular states with larger time steps,...
This National Science Foundation (NSF) Project Grant under CFDA Number 47.041 - Engineering provides $360,000 in funding to Cornell University from July 1, 2023 to June 30, 2026 to develop a novel biosensing platform for the simultaneous detection and quantification of exosomes (small vesicles released from cells) and their molecular cargo. The key objectives are to: (1) develop methods to capture, quantify, and profile exosomes using a plasmonic biosensor; (2) develop techniques to lyse the...
The National Science Foundation (NSF) has awarded a $1,000,000 Project Grant under the Biological Sciences (CFDA 47.074) program to the University of Delaware. The objective of this 3-year grant, which runs from August 2024 to July 2027, is to develop a new strategy for real-time metabolite sensing and metabolon formation using biomolecular condensates. The research aims to create synthetic ligand-responsive transcription factor-based protein devices that can translate metabolite-induced DNA...