Project Grant 2209290
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports the development of new computational tools for analyzing single-cell genomic data across diverse plant species. The $1,180,752 award to Virginia Polytechnic Institute & State University aims to address key challenges in plant single-cell transcriptomics, including determining known and novel cell types, enabling cross-species comparisons, and overcoming the lack of curated...
- The National Science Foundation awarded the University of Georgia Research Foundation, Inc. a $299,072 project grant under the Biological Sciences federal grant program (CFDA 47.074). The grant will support comparative single cell transcriptomics and regulomics research from June 2023 to May 2025. Specifically, the foundation will utilize cutting-edge omics techniques to discover the regulatory components of monoterpene indole alkaloid biosynthesis in two plant species. Researchers will...
- The National Science Foundation awarded a $179,150 Project Grant to the Donald Danforth Plant Science Center under the Biological Sciences federal grant program (CFDA 47.074) for the period of June 15, 2022 through May 31, 2024. The award will support the development of new computational tools and methods to translate single-cell RNA sequencing data into an ultra-high resolution 3D spatial map of gene expression in plant roots. Specifically, the grantee will leverage existing fluorescent...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $300,000 in funding to Western University of Health Sciences to conduct collaborative research on the variability and regulation of the plant polyadenylation complex. The research aims to better understand how this complex mediates gene expression and plant responses to environmental and developmental cues, with the goal of improving our knowledge of crop plant growth,...
- The National Science Foundation awarded a $835,320 Project Grant to Cold Spring Harbor Laboratory under the Biological Sciences federal grant program (CFDA 47.074) for the period January 15, 2023 through December 31, 2025. The grant will support research studying the mechanisms of transport through plasmodesmata in plant cells. Specifically, the grantee will examine the transport of messenger RNAs that encode homeodomain transcription factors, which are important for plant growth and stem cell...
- This $220,848 two-year Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences will fund the development of new approaches for spatial transcriptome analysis in plants under the Biological Sciences program (CFDA 47.074). The awardee, Virginia Polytechnic Institute and State University, will leverage existing fluorescent reporter gene lines to perform single-cell RNA sequencing and fluorescent imaging of the meristematic region of plant roots. Machine...
- This $999,999 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at the Donald Danforth Plant Science Center to elucidate the mechanisms initiating de novo chromatin modification cycles in plant cells. Over three years, the award will support experiments using cutting-edge techniques to dissect the molecular triggers establishing heritable DNA methylation patterns and long-term epigenetic silencing of transposable elements and...
- This $794,457 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will support the development of new genetic analysis tools. The goal is to incorporate molecular and cellular biology knowledge, such as gene expression patterns and regulatory networks, directly into statistical models used to map genes, predict traits, and simulate changes in the genotype-to-phenotype relationships. The research will be conducted using simulated...
- The National Science Foundation awarded a $367,636 Project Grant to the Massachusetts Institute of Technology from March 1, 2021 through February 29, 2024 under the Biological Sciences program (CFDA 47.074). The grant funds collaborative research on multidimensional single-cell phenotyping to elucidate relationships between genomes and phenotypes. The Biological Sciences program aims to advance biological knowledge and understanding of major problems through basic research. This award supports...
- This Project Grant award of $968,613 from the National Science Foundation Division of Molecular and Cellular Biosciences supports research into developing a novel CRISPR synthetic biology tool for investigating and reprogramming alkaloid biosynthesis regulation in Catharanthus roseus. The award was made on March 1, 2021 to Northeastern University for work to be completed by December 31, 2024 under the Biological Sciences program (CFDA 47.074). A sub-award of $100,000 was also provided to...
This three-year, $432,000 National Science Foundation Project Grant under the Biological Sciences program (CFDA 47.074) will fund single-cell research on gene expression and regulatory DNA in glandular trichomes of hemp (Cannabis sativa) flowers. The fellowship, awarded to Lillian Padgett-Cobb and hosted by the Salk Institute for Biological Studies, will apply single-cell experiments including single-cell RNA sequencing and single-cell ATAC sequencing to identify cell types in glandular trichomes and uncover regulatory mechanisms governing metabolite biosynthesis at the single-cell level. Key outcomes include characterization of cell types; identification of regulatory motifs; assessment of sequence variation; and quantification of cannabinoids and terpenoids to correlate with regulatory DNA and gene expression. Sequencing data and analysis scripts will be deposited in public databases. Findings will be published, and broader impacts include educational outreach and undergraduate research mentoring. This award supports the Biological Sciences program's goals of increasing biological knowledge and understanding major problems through basic research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $216.0k | 6/2/22 |