Project Grant 2207688
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded The Trustees of the University of Pennsylvania $1,000,000 under the Biological Sciences federal grant program (CFDA 47.074) from August 2022 through July 2026. The project grant funding will support research combining computer simulations and experiments to better understand the functional significance of cryptic protein surfaces. Specifically, the awardee will explore whether excited protein states that...
- Cornell University received a $100,000 Project Grant award from the National Science Foundation's Technology, Innovation, and Partnerships program to develop a cell-free biosensing platform integrating transmembrane proteins. The award period is from July 1, 2022 to December 31, 2022. Specifically, the university will utilize recent advances in biotechnology and bioelectronics to establish a process for rapidly assembling customized transmembrane proteins into a biomimetic sensing device without...
- This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program provides $410,939 to Clemson University to conduct research on the biophysical mechanisms of membrane protein folding and stability. The project will use advanced single-molecule force spectroscopy techniques, specifically atomic force microscopy, to study how membrane proteins interact with cell membranes and maintain their proper structure. The goal is to gain fundamental biophysical...
- The National Science Foundation awarded Cornell University a $775,595 project grant under the Geosciences program (CFDA 47.050) for the period of January 15, 2021 through December 31, 2023. The grant funds basic research exploring the role of boundary layer microbial remineralization in flavivirus-host dynamics. The Geosciences program supports fundamental knowledge and understanding of the integrated Earth system through basic research in atmospheric, earth, and ocean sciences. Cornell...
- This National Science Foundation (NSF) Mathematical and Physical Sciences (CFDA 47.049) project grant award of $1,500,000 supports research by Dr. Tamar Schlick of New York University and Dr. Alain Laederach of the University of North Carolina at Chapel Hill. The project aims to develop advanced computational tools to predict and control how viral protein synthesis is affected by programmed ribosomal frameshifting (PRF) - the mechanism by which viruses and human cells modify gene expression. Key...
- Cornell University was awarded a $1,317,788 project grant from the National Science Foundation Division of Integrative Organismal Systems to develop tools for host-microbiome protein-protein interaction discovery and establish sequencing-compatible ultra-high-throughput experimental screening approaches. The grant also supports the launch of annual bioinformatics hackathons for students centered on protein structure-inspired projects and the development of computational tools to assign...
- This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $497,000 in funding to the Rochester Institute of Technology (RIT) to conduct research on the mechanobiology of viral infections. The study aims to explore how mechanical forces, such as changes in tissue stiffness and cyclic strain, impact virus-cell interactions in lung tissue. Specifically, the research will investigate how matrix stiffness and cyclic strain affect viral infection...
- This National Science Foundation Project Grant of $365,556 supports collaborative research between mathematicians, biologists, and engineers at the University of Wisconsin-Madison to develop new mathematical tools and biological experiments essential to understanding virus spread and extinction. Funded through the NSF's Biological Sciences program (CFDA 47.074), the research will establish an integrated experimental-mathematical framework to study how spatial structure affects viral evolution...
- This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
- This federal Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program provides $1,000,000.00 to the University of Kansas Center for Research Inc. to determine how the evolution of the coronavirus macrodomain contributes to its biochemical and virological functions. The project will evaluate how viral macrodomains have evolved to develop the ideal biochemical properties that allow them to function during a virus infection, using the mouse coronavirus as...
This $1.8 million project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at Cornell University to develop single molecule tools and techniques for studying coronavirus membrane fusion. The goal is to understand the relationship between coronavirus fusion peptide sequence and target host cell membranes at the nanoscale. Specifically, the awardee will identify and measure the physicochemical interactions between the coronavirus spike protein fusion peptide and host cell membranes that control viral entry and infection. Understanding these interactions could facilitate strategies to limit viral spread and enable predicting characteristics of emerging strains and susceptible host populations. The work is co-funded by NSF programs in Cellular Dynamics and Function and Molecular Biophysics and is expected to be completed by June 2025.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $900.0k | 6/28/22 |