Project Grant 2207050
Award Date
2/1/22
Completion Date
1/31/25
Dollars Obligated
$225K
Federal Agency
Division of Molecular and Cellular Biosciences
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Philadelphia, PA 19104, USA
Similar Awards
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $200,000 in funding to The Trustees of the University of Pennsylvania to conduct collaborative research that aims to understand genomic organization in the cell nucleus. The research team will employ an integrated approach leveraging biophysical modeling, super-resolution imaging, and machine learning to develop predictive models of how chromatin structure and...
The National Science Foundation (NSF) awarded a 5-year, $399,835 CAREER grant under the Biological Sciences program (CFDA 47.074) to the Massachusetts Institute of Technology (MIT) to investigate how transcription and loop extrusion regulate 3D genome structure. The project aims to improve the understanding of how a single genome gives rise to diverse cell types by studying the dynamics of CTCF-mediated DNA loops and topologically associating domains (TADs). The work will integrate advanced...
The Trustees of the University of Pennsylvania were awarded a $185,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences under the Mathematical and Physical Sciences program (CFDA 47.049). The grant will fund the development of testing and estimation methods for multi-modality single cell genomics from August 1, 2021 to July 31, 2024. The University of Pennsylvania will leverage the funding to advance scientific understanding of major problems in...
The Trustees of the University of Pennsylvania received a $526,084 Project Grant from the National Science Foundation Division of Integrative Organismal Systems. The grant is part of the Biological Sciences program (CFDA 47.074) to promote progress in the biological sciences. Under the award, the University will conduct collaborative research to predict plant phenotypes from molecular profiles using topological data analysis and deep learning. Researchers will use X-ray computed tomography to...
This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research into two key areas: 1) understanding how transcription factor families coordinate complex developmental pathways and generate cellular/organismal complexity, and 2) identifying the molecular determinants and relationships that enable robust developmental patterning despite genetic/environmental noise....
This $120,227 project grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program supports research at Northeastern University to develop a new theoretical approach for studying the three-dimensional architecture and conformational ensembles of genes and gene clusters. The project aims to: (i) model the mechanics of chromatin at the gene scale, (ii) investigate how genomic conformations are affected by factors like supercoiling and...
The National Science Foundation awarded a $910,000 project grant to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, to conduct research on the control of shoot apex indeterminacy by the Terminal Flower1 gene. This work, funded through NSF's Biological Sciences program (CFDA 47.074), aims to advance fundamental knowledge on how the maintenance or differentiation of stem cells in the plant shoot apex is regulated. The research...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports advanced microscopy techniques to study the spatial organization and dynamics of cellular components. The $852,726 award will fund research to elucidate how molecular assemblies regulate organelle transport and positioning, how organelle identity links to positioning and function, and the relationship between chromatin...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,218,750.00 to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, for a 5-year research project. The project aims to characterize the regulatory networks and mechanisms of retroelements (RE) - mobile genetic elements that make up nearly half of...