The National Science Foundation awarded a $192,089 Project Grant to the University of Chicago under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) for research titled "Co-Dynamics of Contraction and Adhesion in Animal Morphogenesis." The three-year award beginning March 1, 2022 will support research using advanced microscopy, genetic and biophysical manipulations, and mathematical modeling to gain new insights into the mechanisms governing rapid tissue...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $139,341 project grant to the Regents of the University of California, San Francisco (UCSF) under the NSF Biological Sciences program (CFDA 47.074). The 3-year grant, effective August 1, 2023, supports collaborative research to investigate the biomechanical mechanisms underlying wound resilience in the single-celled organism Stentor coeruleus. The research will leverage cell biology, microfluidics, and...
This $185,422 Project Grant awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research by Northwestern University to identify and characterize proteins involved in controlling the growth of single crystal structures in sea urchin embryos. The goal is to develop a mechanistic understanding of how the expression, localization, and impact of these proteins on nucleation and crystal growth may enable bio-inspired and bio-enabled...
This National Science Foundation (NSF) Project Grant under the Mathematical and Physical Sciences Program (CFDA 47.049) is focused on developing a new generation of computational models for studying eukaryotic cell motility, particularly in complex geometries. The $380,000 award to Northeastern University supports a collaborative project with researchers in France to investigate how cells utilize "blebbing" (pressure-induced protrusions) and nuclear deformation to enable cell...
This $289,687 National Science Foundation project grant supports collaborative research to elucidate the mechanosensing mechanism of the adherens junction core complex through an integrated structural biology approach. Funded under the Biological Sciences program (CFDA 47.074), the research will employ static and dynamic neutron scattering, theoretical physics, and molecular simulation to determine the structure and dynamics of the mechanosensitive core complex that serves as a mechanosensing...
This National Science Foundation project grant of $512,676 will fund research at Duke University from August 2022 to July 2025 under the Biological Sciences program (CFDA 47.074). The research aims to advance understanding of mechanosensitive channels in bacteria through single-molecule force spectroscopy experiments using an atomic force microscope. Investigators will observe the opening of individual mechanosensitive channels in living E. coli and B. subtilis bacteria in response to mechanical...
This National Science Foundation (NSF) Project Grant under the Biological Sciences program (CFDA 47.074) provides $668,572 in funding to Northeastern University to conduct research on the molecular and biophysical mechanisms underlying contractile valve assembly and function. The research aims to characterize the inner structure and regulatory mechanisms of a donut-shaped contractile valve in the reproductive system of the nematode C. elegans, using advanced microscopy, genetic perturbations,...
The National Science Foundation awarded a $367,636 Project Grant to the Massachusetts Institute of Technology from March 1, 2021 through February 29, 2024 under the Biological Sciences program (CFDA 47.074). The grant funds collaborative research on multidimensional single-cell phenotyping to elucidate relationships between genomes and phenotypes. The Biological Sciences program aims to advance biological knowledge and understanding of major problems through basic research. This award supports...
The University of Chicago received a $206,128 National Science Foundation project grant under the Biological Sciences federal grant program (CFDA 47.074) to conduct collaborative research from June 1, 2023 through May 31, 2027. The research aims to elucidate the mechanism of myoneme contraction in the ciliate Spirostomum ambiguum, a model system for understanding force generation. The university will determine the factors modulating assembly and force generation of myonemes, the contractile...