Formula Grant 2201TXOAPH

The National Eye Institute (NEI) awarded a $245,243 Project Grant (CFDA 93.867 - Vision Research) to Duke University to develop and validate a novel method for measuring ocular pulse amplitude (OPA) using fixed force applanation tonometry. The project aims to: 1) validate the applanation-based OPA measurement technique on non-human primates implanted with an intraocular pressure telemetry system in normotensive and hypertensive eyes, and 2) assess the repeatability and reproducibility of the OPA...

This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $257,429 to the University of Miami to conduct research aimed at preventing or eliminating unwanted immune responses towards adeno-associated virus (AAV)-delivered anti-HIV antibodies. The key objectives are to 1) induce tolerance towards AAV-delivered antibodies using a combination of immunomodulatory drugs (rapamycin and ibrutinib) prior to and during AAV...

This $320,000 Project Grant award from the National Institute on Aging (NIA) under the Aging Research Program (CFDA 93.866) supports research to investigate the impact of Alzheimer's disease-related tau protein dysfunction on alternative polyadenylation (APA) regulation and RNA processing in neurons. The primary objectives are to: 1) Comprehensively profile APA transcripts and gene expression in mouse primary hippocampal neurons expressing wild-type vs. pathogenic mutant tau proteins, and 2)...

This $1,352,267 federal Formula Grant award from the U.S. Department of Housing and Urban Development (HUD) under the Housing Opportunities for Persons with AIDS (HOPWA) program provides funding to Asociacion Puertorriquenos En Marcha, Inc. (APM), a nonprofit organization serving the Philadelphia area. The grant supports APM's provision of tenant-based rental assistance (TBRA) to 43 households, permanent housing placement services for 43 households, and supportive services for 43 low-income...

The One World Recovery Network (OWRN) received a $2,269,432 Project Grant from the Health Resources and Services Administration (HRSA) under the Mental and Behavioral Health Education and Training Grants program (CFDA 93.732). The grant will fund the establishment of a Department of Labor credentialed Registered Apprenticeship Program (RAP) to strengthen peer-based recovery support systems in three medically underserved Texas counties: Jefferson, Grayson, and Lubbock. Key services to be provided...

This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development of a new high-throughput assay to measure the formation of amyloid-beta (Aβ) oligomers, which are of high interest for Alzheimer's disease research. The $219,930 award, spanning from September 15, 2024 to June 30, 2027, will enable the University of Wisconsin - Madison to create a genetically encoded sensor that can detect Aβ oligomer formation and convert it into a...

This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), is supporting the development of a single-vector gene therapy treatment for autosomal-dominant retinitis pigmentosa (ADRP). The funded project, led by Opus Genetics Inc., is focused on advancing the chemistry, manufacturing, and controls (CMC) for the OPGX-RHO gene therapy candidate, as well as evaluating its efficacy and safety in additional large animal models. The total funding for...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $431,750 to support the development of a novel immuno-gene therapy for tauopathies, a group of neurodegenerative diseases including Alzheimer's disease. The award will fund the generation and validation of a single-chain fragment variable (scFv) derived from an anti-tau oligomeric complex 1 (TOC1) antibody, which will be delivered via recombinant adeno-associated viruses (AAVs) to specifically...

This Project Grant Award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $766,672 to Harvard Pilgrim Health Care Inc. to assess the acceptability, feasibility, and potential impact of making HIV pre-exposure prophylaxis (PrEP) available over-the-counter (OTC) in the United States. The key objectives are to: 1) survey diverse populations, including cisgender men who have sex with men, transgender women, and cisgender women, to...

The Montgomery County Assisted Outpatient Treatment (AOT) Program is a $1,500,000 project grant awarded by the Substance Abuse and Mental Health Services Administration (SAMHSA) under the CFDA 93.997 Assisted Outpatient Treatment Program. The grant aims to reduce psychiatric hospitalizations, homelessness, incarceration, and interactions with the criminal justice system while improving the health and social outcomes of individuals with severe mental illness in Montgomery County, Ohio. The...