Project Grant 2200534
- The Morehouse School of Medicine (MSM) received a $996,072 Project Grant award from the National Science Foundation (NSF) Integrative Activities (CFDA 47.083) program. The grant will support research to investigate the role of the acid-sensing ion channel 1A (ASIC1A) in neuronal development and maturation. Through a combination of molecular biology, imaging, electrophysiology, pharmacology, proteomics, and in vitro/in vivo models, the project aims to systematically examine how ASIC1A contributes...
- This $495,341 Project Grant was awarded by the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program to the Morehouse School of Medicine, Inc. (MSM) on July 1, 2025 with a completion date of June 30, 2027. The grant will support a research project focused on understanding the signaling pathways that regulate the late-stage maturation of new neurons in the adult hippocampus, a brain region important for memory and spatial navigation. Specifically, the project...
- This $1.5 million Project Grant from the National Science Foundation (NSF), under the Engineering federal grant program (CFDA 47.041), will fund research at the University of California Irvine from October 2022 through September 2026. The university will develop hydrogel-based bioengineering technologies to reproducibly generate distinct spatial organization and cellular diversity within cortical organoids, mimicking the development of different brain regions. Researchers will leverage expertise...
- This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at Indiana University to investigate the role of epigenetic mechanisms in regulating gene expression programs during the development of the cerebral cortex in mammals. The project aims to elucidate how specific histone modifications influence neurogenesis and cell fate specification, with the goal of enhancing fundamental understanding of mammalian, including...
- This Project Grant award from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) provides $878,496.00 to the Morehouse School of Medicine, Inc. (MSM) from May 1, 2025 to April 30, 2028 to conduct research on the role of STAT5 signaling in placental dysfunction, inflammation, and fetal immune activation. The project aims to bridge the gap in understanding innate immune signaling at the placenta and identify mechanisms associated with placental development and...
- The National Science Foundation awarded a $1,099,733 project grant to the University of Arizona under the Biological Sciences program (CFDA 47.074) to investigate neural stem cell mechanisms of resilience across the lifespan. Over a four-year period ending August 2026, the university will study how neural stem cells change at the cellular, molecular, and functional levels over time using aging rodent models. The project will specifically examine the role of female sex hormones estrogen and...
- The National Science Foundation (NSF) awarded a $399,978 Project Grant under the STEM Education (formerly Education and Human Resources) program (CFDA 47.076) to the College of Charleston. The grant aims to develop and test a web-based platform that uses neural connectivity data to improve student learning of neuroanatomy. Key products to be delivered include: Revising and expanding an interactive graphical software system called "Show Me the Brain!!" to include 3D models of...
- The National Science Foundation (NSF) Engineering Directorate awarded a $564,510 Project Grant to the University of Massachusetts (UMass) to develop an engineered neural organoid system with improved brain regionalization and integrated mesh electrodes for enhanced monitoring and stimulation capabilities. The key objectives of this 3-year grant project are to: 1) Assemble regionalized neural organoids that enable thalamus-subpallium-cortex projections by stacking sliced organoids, 2) Innervate...
- The National Science Foundation (NSF) awarded a $550,000 Project Grant under the Biological Sciences (CFDA 47.074) federal grant program to Georgetown University. The 5-year grant, effective April 1, 2025, supports research to understand how changes in the extracellular matrix surrounding synapses affect synapse stability and brain function. This work aims to uncover the mechanisms that preserve brain connectivity, with potential to inspire new strategies for addressing neurological disorders...
- This Project Grant award, provided by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), will support research to investigate how the three-dimensional organization of the human genome controls gene expression and cell identity in the brain. The $300,000 award, spanning August 2025 to July 2027, will fund the development of new AI-powered tools to reconstruct 3D chromosome structure from single-cell experiments and simulate how changes in genome structure affect...
The Morehouse School of Medicine, Inc. will conduct research on the role of neuregulin-1 in proliferation and differentiation of brain cortical neuronal stem cells during fetal development under a $1,681,744 Project Grant from the National Science Foundation Office of Integrative Activities. The research will examine how neuregulin-1 mediates normal brain cortical development through signaling pathways involving regulators of cell cycle, neural migration, differentiation and maturation. Experiments using human cortical organoids and mouse models will clarify neuregulin-1/ErbB4 signaling's role in brain development. The grant also supports mentoring of underrepresented students and postdoctoral fellows in organoid tissue engineering research. This award advances the National Science Foundation's Integrative Activities program goal of enhancing the nation's STEM enterprise through capacity building and broadening participation in research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $840.9k | 6/30/22 |