Project Grant 2151149
Award Date
4/1/22
Completion Date
3/31/23
Dollars Obligated
$256K
Funding Federal Agency
Division of Industrial Innovation
Awarding Federal Agency
National Science Foundation
Awardee
Ezrabio Inc. (D2D8K4BWTEP7)
Federal Grant Program
47.041
Assistance Type
Project Grant
Place of Performance
Ithaca, NY, USA
Similar Awards
This $3,000,000 project grant, awarded by the National Science Foundation (NSF) under the Engineering (CFDA 47.041) program, aims to solve the long-standing challenge of developing self-amplifying ribonucleic acid (SARNA) technologies. The project, led by Trustees of Boston University, a private non-profit research university, will: Synthesize a diverse library of modified nucleoside triphosphates (ModNTPs) and use them to produce modified SARNA with extended cellular half-life. Evaluate the...
This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) provides $383,482 to Electronic Biosciences, Inc. to develop the SPINSEQ platform, an innovative RNA sequencing technology. The goal is to create a highly precise and accurate solution for transcriptomic and epitranscriptomic analysis that can overcome the limitations of existing RNA sequencing methods. Key focus areas include maintaining RNA integrity, ensuring accurate sequencing,...
This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) provides $350,000 to Electronic Biosciences, Inc. to develop a novel technology for high-accuracy sequencing of pseudouridine (Ps) and N6-methyladenosine (M6A) RNA modifications. The project aims to merge Professor Cynthia J. Burrows' bisulfite adduct methodology with Electronic Biosciences' nanopore sequencing platform to create the first sequencing...
This National Science Foundation (NSF) Small Business Innovation Research (SBIR) Phase I project under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) aims to develop a next-generation sequencing platform for discovering small molecules that target RNA. The $303,445 award to Endura Therapeutics Inc. in San Diego, CA will establish an assay to detect RNA-drug interactions and identify RNA structures amenable to small molecule binding. The goal is to address...
This $350,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development and demonstration of a novel, enzyme-based, single-molecule protein sequencing system by Electronic Biosciences, Inc. The innovative platform aims to leverage enzymatic processing and advanced bioinformatics to enable scalable, multiplexed protein sequencing with high accuracy and throughput. During this Phase I...
This $750,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of a novel platform to enable rapid and robust identification of functional RNA molecules directly within mammalian cellular environments. The research aims to solve the challenge of RNA structure sensitivity to local environments that has hindered progress in the field of functional RNA discovery. The project will deliver a customized...
This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $750,000 to Stanford University to develop new technologies for studying RNA, the essential molecules that carry genetic information and play crucial roles in cell functions. The key products and services to be delivered under this 3-year award include: Creating non-destructive methods to directly study RNA localization and interactions within living cells, achieving...
This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), will provide $215,088 to Directseq Biosciences, Inc. to develop an exhaustive de novo RNA sequencing method using next-generation mass spectrometry (NGMS-seq). The objective is to create a technology that can directly identify and sequence every RNA species in a sample, while also comprehensively profiling all RNA modifications, without bias....
The National Science Foundation (NSF) Division of Integrative Organismal Systems awarded a $299,983 Project Grant to North Carolina State University (NCSU) under the agency's Biological Sciences program (CFDA 47.074). The objective of this 2-year grant is to develop a new biotechnology called RIBOPI that will enable efficient, scalable, and cost-effective quantification of gene-specific translation regulation. RIBOPI aims to make translation regulation analysis as accessible as RNA sequencing...
This Project Grant award of $408,007 from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop a technology called "glycosequencing" that uses next-generation sequencing (NGS) to sequence and quantify glycan structures. The project will first identify an optimal set of lectins, biochemically characterize them, and prepare lectin barcoding for NGS. It will also build a training dataset using recombinant proteins produced in glycoengineered Chinese...