Project Grant 2142727
- This $100,000 Project Grant awarded by the National Science Foundation's Biological Sciences program (CFDA 47.074) will support the development of deep-learning models, specifically consistency models, to simulate the long-time-scale dynamics of protein structures. The project aims to address the limitations of current molecular dynamics (MD) simulations in capturing crucial long-duration protein dynamics events, such as protein folding and aggregation. By developing these advanced computational...
- This $526,873 federal Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research at the University of California, Riverside on the mechanisms of protein-protein associations facilitated by molecular "glues". The research aims to computationally model and experimentally investigate how these molecular glues mediate the formation of protein complexes and enhance their biological functions. The project will contribute to...
- This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program provides $410,939 to Clemson University to conduct research on the biophysical mechanisms of membrane protein folding and stability. The project will use advanced single-molecule force spectroscopy techniques, specifically atomic force microscopy, to study how membrane proteins interact with cell membranes and maintain their proper structure. The goal is to gain fundamental biophysical...
- This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
- This National Science Foundation Project Grant of $536,946 will support research at the University of California, San Diego from September 2022 through August 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). The award will fund the development of rigorous scientific theories and powerful computational tools to model biomolecular interactions. Researchers will design advanced numerical methods to simulate drug and protein binding/unbinding kinetics, incorporating molecular...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded The Trustees of Columbia University in the City of New York a $1,200,000 Project Grant on March 15, 2025 to develop and apply a method of time-resolved cryo-electron microscopy (cryo-EM) to diverse biological molecules of medical importance. The project aims to use newly designed PDMS-based microfluidic chips to apply the time-resolved cryo-EM sample preparation technique, which has been...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $785,201 Project Grant to The Regents of the University of Colorado to support research titled "Collaborative Research: Understanding Protein Mechanical Stability and Its Impact on Secretion." The two-year grant running from January 15, 2022 to December 31, 2024 will fund research under the Biological Sciences program (CFDA 47.074). The Biological Sciences program aims to promote progress in the...
- The National Science Foundation (NSF) awarded a $253,890 Project Grant under the Biological Sciences program (CFDA 47.074) to Western University of Health Sciences to conduct research on sensory membrane proteins. The goal is to develop computational tools capable of realistic simulations of how these proteins respond to external stimuli like pressure, heat, and sound. The research project, titled "Collaborative Research: Ultra-Fast Simulations of Sensory Membrane Proteins with Validation...
- The National Science Foundation awarded a $538,838 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to The Regents of the University of California, San Francisco for research titled "Collaborative Research: Mapping Protein-Membrane Interactions from Molecules to Cell-Level Dynamics." The research will develop multiscale models to map how individual protein structures and compositions interact with and deform cell membranes at varying scales, from...
- The University of Southern California was awarded a $1,599,992 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences. The grant is part of the NSF's Biological Sciences program (CFDA 47.074) to support basic research that advances understanding of major problems in the biological sciences. Under this award, USC will conduct research from August 2021 through July 2025 to modularize and minimize the yeast transcription factor repertoire. The goal is to...
This five-year $1.5 million Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences will fund computer simulations and modeling of G-proteins, molecular machines, and other biomolecules at the University of Southern California. The grant supports research into understanding the control and mediation of life processes by G-proteins and related complexes, the role of ATP in specialized proteins and energy conversion processes, directional motions of biological motors, and the activation of G protein-coupled receptors. The principal investigator will conduct ab initio quantum mechanics/molecular mechanics studies of key biomolecular systems and reactions, including rotary motors, myosins, G-proteins, and elongation factor Tu. This award is aligned with the goals of the Biological Sciences program (CFDA 47.074) to strengthen the biological sciences through increased knowledge and understanding of major problems in the field.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 1/28/22 |