This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $382,801 to the University of California, Los Angeles (UCLA) to develop a new class of artificial RNA condensates that can be used as customizable organelles inside living cells. The project aims to: (1) optimize the sequence and structure of RNA nanostars to produce condensates with desired properties and affinity for separating...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award provides $270,000 to fund a 3-year postdoctoral fellowship focused on elucidating the relationship between the structure and enzymatic activity of biomolecular condensates. The research will investigate how the physical and chemical properties of these cellular compartments, which lack membranes, influence the activity of enzymes recruited into them. The fellow will receive training in advanced imaging...
This $300,000 Project Grant award from the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083) supports the development and experimental validation of computational tools for simulation-guided design of DNA nanostructures and molecular systems. The research goal is to integrate high-level kinetic models with low-level molecular dynamics models to create novel multiscale modeling frameworks for DNA nanotechnology. The project will also parameterize coarse-grained...
This $300,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will support research into the structural biology of RNA and RNA-protein interactions through May 2024. Funded under the Biological Sciences program (CFDA 47.074), this award to Vanderbilt University will utilize joint cryo neutron/x-ray crystallography techniques to better understand the importance of the 2'-hydroxyl group in RNA's expanded three-dimensional structure compared to DNA....
The University of Utah will receive $829,999 from the National Science Foundation under the Biological Sciences federal grant program (CFDA 47.074) for the project "Molecular Evolution of Cellular Condensates" from August 15, 2022 to July 31, 2025. The university will analyze condensate constituents in the model organism Caenorhabditis elegans to understand how these membrane-less organelles form and evolve at the molecular level. Researchers will conduct phylogenetic analysis of...
The Regents of the University of California, San Francisco (UCSF) received a $284,636 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences (CFDA 47.074) federal grant program. The two-year award will support research establishing novel tools to artificially manipulate chromosome folding and modulate various genome functions, including enhancer regulation of gene expression. Specifically, the grant will fund...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant, awarded to the Regents of the University of California at Riverside, provides $526,873 in funding from December 15, 2024 to November 30, 2027. The grant supports computational research to simulate protein-glue-protein binding and dissociation, in order to characterize molecular glue spots, elucidate glue-mediated protein associations, and uncover the reasons for protein co-localization in cells. The...
This $236,662 National Science Foundation award through the Mathematical and Physical Sciences program (CFDA 47.049) funds research at Emory University to develop novel biomimetic materials capable of simultaneously encoding both nucleic acid and protein information codes to control assembly and function. Specifically, the award supports exploration of "bilingual biopolymers" using peptide nucleic acid as a scaffold to direct structure based on both peptide and nucleic acid...
This National Science Foundation (NSF) grant award under the Mathematical and Physical Sciences program (CFDA 47.049) provides $536,802 to the University of Massachusetts Amherst to develop an advanced coarse-grained molecular modeling framework for simulating the phase transitions and condensate formation of flexible RNA molecules. Specifically, the project aims to: 1) accurately model the temperature and magnesium ion-dependence of RNA structure and phase separation; 2) elucidate the interplay...
This $100,000 Project Grant, awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), will fund research led by Dr. John Chaput at the University of California, Irvine to elucidate the mechanism of DNA synthesis using time-resolved X-ray crystallography. The goal is to capture detailed snapshot images of the catalytic steps involved in DNA replication, providing a comprehensive understanding of this fundamental biological process at the atomic level. This...