This National Science Foundation Project Grant of $921,054 supports research to develop new biological functions through engineering plant hormone receptors. Led by the Regents of the University of California, Riverside under the Biological Sciences program (CFDA 47.074), the project engineers plant sensors to recognize pharmaceuticals and dietary molecules. It then uses these sensors to design "sentinel cells" that indicate molecule presence through color changes. Specifically, the...
This $234,063 National Science Foundation (NSF) project grant, awarded under the NSF Engineering program (CFDA 47.041), seeks to engineer plants to produce enhanced therapeutic proteins and improve protein production performance. The key objectives are to: 1) investigate the glycosylation and functions of glycosyl-phosphatidyl-inositol (GPI)-anchored proteins (GPI-APs) engineered in plant cells; 2) assess the broader applicability and potential applications of GPI-APs in plant cells; and 3)...
This $350,000 Project Grant award from the National Science Foundation's (NSF) Office of International Science and Engineering (CFDA 47.079) will fund the Engineered Plants in Culture (EPIC) biomanufacturing research project at the University of California, Davis. The objective is to develop small-scale, self-sufficient biomanufacturing processes using engineered plant cells, plant embryos, and fast-growing aquatic plants as production platforms. Key research challenges include improving plant...
This National Science Foundation (NSF) Project Grant award, funded under the Engineering (CFDA 47.041) program, aims to develop a low-cost, mRNA-based manufacturing process for producing chimeric antigen receptor (CAR) T-cell therapies. The $250,000 award, effective May 1, 2025 through April 30, 2027, supports research to investigate protein expression and half-life in electroporated T-cells with mRNA, as well as the feasibility of using machine learning to create GMP-compliant...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences and the Division of Chemical, Bioengineering, Environmental and Transport Systems awarded a $240,000 Project Grant to the University of California Irvine (UC Irvine) under the NSF Biological Sciences program (CFDA 47.074). The grant supports collaborative research to develop unnatural cofactors that can be deployed as stronger-than-nature thermodynamic driving forces in biomanufacturing processes. This is...
The National Science Foundation (NSF) awarded a $274,980 SBIR Phase I Project Grant to Cisterna Biologics, Inc. to develop a novel platform for cost-efficient mRNA production in yeast. The project aims to transform yeast cells into efficient mRNA factories and utilize advanced chromatographic techniques for purification, with the goal of reducing mRNA manufacturing costs by 90% compared to current in vitro transcription methods. Key technical objectives include demonstrating stable mRNA fusion...
The National Science Foundation (NSF) awarded a $800,000 Project Grant under its Biological Sciences program (CFDA 47.074) to The Regents of the University of California, doing business as University of California, Berkeley. The grant funding will support collaborative research to discover and characterize compact CRISPR gene editing systems that can be encoded in plant viruses. This will enable more efficient and widespread deployment of genome editing capabilities across a variety of crop...
The National Science Foundation awarded a $325,309 Project Grant to the University of Massachusetts Lowell's Office of Research Administration to support collaborative research titled "CONTINUOUS BIOMANUFACTURING USING DECOUPLED GROWTH AND PRODUCTION STAGES FOR EFFICIENT PRODUCTION AND RECOVERY." The research is funded under the NSF Directorate for Engineering's CFDA #47.041 Engineering program and aims to improve biomanufacturing processes through continuous and decoupled growth and...
This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program provides $500,000 from March 2024 through February 2027 to researchers at the University of Maryland and Silvec Biologics, Inc. to develop methods to stabilize RNA genomes in viruses that can be used as therapies to treat plant diseases. The project aims to use computational approaches, including artificial intelligence, to design RNA structures that can be inserted into virus genomes to increase...
This two-year, $512,200 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports the development of a microbial "foundry" for distributed manufacturing of mRNA-containing biomaterials. Awarded on September 1, 2021 to Purdue University with a completion date of August 31, 2023, the grant will further the program's goals of advancing the biological sciences and strengthening the national scientific enterprise. Under this award, Purdue...