Project Grant 2120909
- This two-year, $200,000 Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems will fund research at the Long Beach Research Foundation to develop multi-activity proteins for improved carbohydrate deconstruction. Specifically, the Foundation will produce and test 85 engineered multi-activity proteins containing two catalytic domains each. These proteins aim to increase biomass conversion for alternative fuels and...
- This $256,000 Project Grant was awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program. The award to Terragia Biofuel Inc., a for-profit organization, aims to develop innovative bioprocessing technologies for converting lignocellulosic biomass into hydrocarbon fuels and products. Specifically, the project is focused on demonstrating the feasibility of a technique called Continuous Evolution with Multiplex Natural Transformation...
- This National Science Foundation (NSF) Engineering program (CFDA 47.041) Project Grant of $545,000 awarded May 15, 2025, supports research to enhance recombinant protein production in Komagataella pastoris (Pichia pastoris), a food-safe yeast widely utilized in biomanufacturing and biological research. The research will deliver scientific outcomes demonstrating how codon usage patterns can be exploited to maximize recombinant protein expression while simultaneously preserving host cellular...
- This Project Grant award from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) provides $369,297 to San Francisco State University (SFSU) to develop a synthetic transhydrogenation module to enhance the production of valuable chemicals using engineered organisms. The key objectives are to: Elucidate the structural mechanisms underlying the autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism and impacts...
- This two-year National Science Foundation Project Grant of $199,998 provides funding for modeling bacterial microcompartment assembly using a multiscale computational framework. The grant is awarded under the NSF Engineering program (CFDA 47.041) to the Colorado School of Mines to investigate the Haliangium ochraceum microcompartment. Researchers will quantify protein oligomerization free energy landscapes and classify molecular determinants controlling microcompartment morphology using...
- This National Science Foundation (NSF) grant under the Engineering program (CFDA 47.041) provides $360,000 to the University of Tennessee to develop innovative microbial communities capable of converting organic waste into renewable biogas through a process known as electro-methanogenesis. The key objectives are to: Build robust electro-methanogenic microbial communities by continuously switching the direction of electricity, enabling both organic-consuming and biogas-producing microorganisms to...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $750,000 Project Grant to The Washington University in St. Louis to support research and training related to understanding how metabolic burdens affect microbial cells used in biotechnology applications. The 3-year award, which commenced on August 15, 2023, will enable the Principal Investigator to acquire expertise in modern metabolomics and gene editing techniques, and apply these methods to...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $400,000 Project Grant to the Regents of the University of California at Riverside under the Engineering (47.041) federal grant program. The three-year award will support collaborative research using machine learning and synthetic biology approaches to engineer the thermotolerant yeast Kluyveromyces marxianus to maximize production of malonyl-coA, a key precursor to polyketides....
- The National Science Foundation (NSF) awarded a $500,000 Project Grant under the Engineering program (CFDA 47.041) to the South Dakota School of Mines & Technology. The primary objective of this 2-year award is to develop a cell-free method for producing biodegradable polyhydroxyalkanoate (PHA) polymers from agricultural feedstocks. Key anticipated research activities include: 1) engineering a microbial strain to synthesize PHA precursors from corn stover, 2) using thermostable enzymes...
- This two-year, $512,200 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports the development of a microbial "foundry" for distributed manufacturing of mRNA-containing biomaterials. Awarded on September 1, 2021 to Purdue University with a completion date of August 31, 2023, the grant will further the program's goals of advancing the biological sciences and strengthening the national scientific enterprise. Under this award, Purdue...
PFI (MCA): TRANSLATION AND EDUCATION OF HIGH-THROUGHPUT MICROBIAL STRAIN ENGINEERING -THE BROADER IMPACT/COMMERCIAL POTENTIAL OF THIS PARTNERSHIPS FOR INNOVATION ? MID CAREER ADVANCEMENT (PFI-MCA) PROJECT IS TWO-FOLD: TO DRAMATICALLY ADVANCE MICROBIAL ENGINEERING TECHNOLOGIES FOR BIOFUEL AND BIOCHEMICAL PRODUCTION TOWARDS MAXIMAL IMPACT; AND TO DEVELOP NEXT-GENERATION ENGINEERS WITH ENTREPRENEURIAL MINDSETS AND SKILLS, THROUGH MODERNIZING THE UNDERGRADUATE AND GRADUATE CURRICULA IN CHEMICAL ENGINEERING. THIS PROJECT WILL DEVELOP BIOTECHNOLOGIES APPLICABLE TO A WIDE RANGE OF MICROBIAL SPECIES AND DIVERSE APPLICATIONS, POTENTIALLY DEVELOPING SUSTAINABLE SUBSTITUTES TO PETROCHEMICALS. THE PROJECT WILL ALSO DEVELOP ENTREPRENEURIAL TRAINING FOR COHORTS OF UNDERGRADUATE AND GRADUATE STUDENTS, PARTICULARLY FEMALE AND UNDERREPRESENTED MINORITY (URM) STUDENTS. THE PROPOSED PROJECT WILL ADVANCE MICROBIAL ENGINEERING TECHNOLOGIES FOR BIOFUEL/BIOCHEMICAL PRODUCTION, PARTICULARLY HIGH-THROUGHPUT STRAIN ENGINEERING AND SCREENING. THIS PROJECT WILL: I) EXTEND NEW APPROACHES FOR MICROBIAL ENGINEERING FROM LABORATORY MODEL SYSTEMS TO A RANGE OF INDUSTRIALLY RELEVANT MICROBIAL ORGANISMS AND BIOMOLECULES; II) IDENTIFY AND ADDRESS BOTTLENECKS IN PROCESS SCALE-UP; AND III) DEVELOP AND DELIVER NEW EDUCATIONAL COMPONENTS AND MODULES FOR INCORPORATING ENTREPRENEURIAL TRAINING INTO UNDERGRADUATE AND GRADUATE CURRICULA. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 5/2/25 | ||
| Not listed | $381.8k | 1/26/22 |