This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the agency's Biological Sciences program (CFDA 47.074) provides $680,000 from August 1, 2023 to July 31, 2026 to the University of Chicago. The project aims to understand the sequences in pre-mRNA that determine which exons are removed during RNA splicing, a critical process in eukaryotic cells for generating mature messenger RNAs. The research will use high-throughput...
The National Science Foundation awarded a $252,937 Project Grant under its Mathematical and Physical Sciences program (CFDA 47.049) to the University of Chicago. The purpose of this 3-year grant, which runs from September 1, 2023 to August 31, 2026, is to enhance statistical methods for analyzing temporally observed, multi-sample data in fields such as environmental science, epidemiology, and economics. The research team will develop innovative approaches to estimate and infer trends in data...
The National Science Foundation (NSF) awarded a $219,268 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of Chicago. The grant, effective July 1, 2024 through June 30, 2027, will support collaborative research on "Statistical Inference for High Dimensional and High Frequency Data: Contiguity, Matrix Decompositions, Uncertainty Quantification." The research aims to develop advanced mathematical and statistical methodologies to extract...
The University of Chicago received a $160,000 Project Grant award from the National Science Foundation (NSF) Division of Mathematical Sciences. The grant, awarded on October 1, 2023, will fund a research project dedicated to advancing robust estimation techniques to address the challenge of data contamination in modern scientific studies. The primary objectives are to develop innovative methods for robust high-dimensional estimation and robust nonparametric interpolation, enabling the...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $414,164 Project Grant under the Biological Sciences CFDA program to the University of Illinois at Chicago. This 3-year grant, awarded on August 15, 2023, will support research to study how enzymes in intermediary metabolism interact with and bind to RNA molecules. The project aims to gain a greater understanding of these protein-RNA interactions and their effects on regulating cellular activities,...
The National Science Foundation awarded a $1,646,031 project grant under the Biological Sciences program (CFDA 47.074) to the University of Chicago for research titled "Combining Models and Data to Understand the Spatial Dynamics of Host-Pathogen Interactions." The grant period is from July 1, 2021 to June 30, 2025. The University of Chicago will lead research using mathematical models and data analysis to understand spatial dynamics between hosts and pathogens. Subawards were provided...
This $155,372 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program will fund research to develop advanced statistical methods for extracting insights from high-dimensional, high-frequency "big data." The University of Illinois, Chicago, as the prime awardee, will focus on four key areas: 1) advancing contiguity theory to enable more robust statistical analysis of noisy, high-frequency data; 2) exploring time-varying...
The National Science Foundation (NSF) awarded a $1,199,997 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Colorado-Denver. The grant will fund research to improve understanding of the mechanisms underlying messenger RNA (mRNA) localization and translation, and develop machine learning models to better predict protein production from mRNA. The project will apply recent advancements in RNA sequencing technology to study how factors like tRNA abundance and...
The University of Chicago was awarded a $238,603 project grant from the National Science Foundation to conduct research at the intersection of conformal field theory, cryo-electron microscopy, and neural networks from July 1, 2021 through June 30, 2024. The grant was awarded under the NSF's Mathematical and Physical Sciences program (CFDA 47.049), which aims to strengthen the nation's scientific enterprise through increased understanding of major problems. Through this funding, the University...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $1,867,312 to the University of Chicago to uncover the mechanisms of cell-type-specific pre-mRNA splicing. The primary objectives are to: 1) Uncover cis-regulatory elements and coordinated splicing patterns using single-cell long-read sequencing; 2) Study redundant RNA-binding protein functions through multiplexed genome...