Project Grant 2102225

This three-year Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems will support the development of new green-chemical catalysts based on Rieske dioxygenase scaffolds through directed evolution at Ball State University. Totaling $366,434, the award aims to evolve previously uncharacterized dioxygenases found in soil bacteria to expand their substrate ranges for valuable applications in organic synthesis and...

This Project Grant award of $270,000.00 from the National Science Foundation's Biological Sciences (CFDA 47.074) program funds a postdoctoral research fellowship focused on understanding the "cost of complexity" in multifunctional rhodopsin genes from cyanobacteria. The research seeks to determine how maintaining multiple functions, such as proton pumping and light absorption, impacts the ability of these genes to adapt to changing environmental conditions. The project will...

This Project Grant award from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) provides $369,297 to San Francisco State University (SFSU) to develop a synthetic transhydrogenation module to enhance the production of valuable chemicals using engineered organisms. The key objectives are to: Elucidate the structural mechanisms underlying the autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism and impacts...

Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded University of California, Los Angeles $420,981 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the directed evolution of biocatalysts for asymmetric hydrogen atom transfer reactions. The five-year project, concluding February 28, 2031, will develop engineered enzymatic catalysts capable of catalyzing metal-hydride-mediated...

This Project Grant award in the amount of $248,930 from the National Science Foundation (NSF) Division of Chemistry's Broadening Participation (CHE-BP) program supports research by Professor Miller and undergraduate students at Indiana State University. The project aims to study the chemical modification of signaling molecules from the bacterium Pseudomonas aeruginosa, which uses these small molecular signals to coordinate responses and grow in diverse environments. Specifically, the researchers...

This $1,972,972 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research into novel synthetic methodologies for preparing complex bioactive molecules. Conducted by UC Berkeley from May 2025 through April 2030, the project focuses on discovering simplified synthetic disconnections and strategies to efficiently synthesize biologically important diterpenes from the plant families...

The National Institute of General Medical Sciences (NIGMS) awarded a $216,906 Project Grant to The Regents of the University of Colorado, doing business as the University of Colorado Office of Contracts and Grants Division, to conduct research on the "Evolution of Novel Metabolic Pathways" under CFDA Program 93.859 - Biomedical Research and Research Training. The funding will support the University's efforts to study how organisms can evolve new metabolic pathways to access new...

This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $665,885 to the Woods Hole Oceanographic Institution (WHOI) to conduct collaborative research on the evolution of acquired phototrophy in Mesodinium ciliates. The key products and services to be delivered under this 3-year award, which began on March 1, 2024, include: Comparative studies of the cellular, metabolic, and genetic adaptations across a genus of Mesodinium ciliates that...

This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $730,000 to the University of California, Los Angeles (UCLA) aims to transform the field of protein engineering through the development of an innovative technology called PicnnnShells. PicnnnShells are tiny, hollow particles that can rapidly screen up to one million different protein variations in a single day to identify useful proteins for research, industrial or medical applications. The...

The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $400,000 Project Grant to the Regents of the University of California at Riverside under the Engineering (47.041) federal grant program. The three-year award will support collaborative research using machine learning and synthetic biology approaches to engineer the thermotolerant yeast Kluyveromyces marxianus to maximize production of malonyl-coA, a key precursor to polyketides....