Project Grant 2047583

This Project Grant award from the National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $343,203 to Cyion Technologies LLC to develop a novel in vitro electrophysiology system for high-throughput measurement of intracellular action potential (IAP) in human-derived cardiomyocytes. The system leverages a 3D nanoelectrode array (NEA) technology to enable scalable recordings of IAP signals from many individual cardiomyocytes. This...

The National Science Foundation (NSF) Engineering program awarded a $695,746 CAREER grant to The Washington University's Office of Sponsored Research Services Division to support research aimed at understanding how to grow more mature heart muscle from induced pluripotent stem cells (iPSCs) in the laboratory. The research project will investigate how combining mechanical loading and changes in energy sources can enhance the electrical maturation of iPSC-derived cardiomyocytes to better predict...

This National Science Foundation (NSF) Faculty Early Career Development (CAREER) Program award, funded under CFDA 47.041 Engineering, aims to enhance the understanding of mechanisms driving cardiac arrhythmias. The $418,901 project, awarded on February 1, 2025, with a completion date of January 31, 2030, integrates complex computational simulations of electrical, mechanical, and fluid dynamics with advanced deep-learning techniques. This holistic research pathway will uncover how multiple...

This $169,974 federal project grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research conducted by The General Hospital Corporation (Massachusetts General Hospital) to investigate the role of non-canonical WNT signaling in the pathogenesis of atrial fibrillation. The key objectives of this 5-year project are to: 1) expand understanding of how ZFHX3 deficiency leads to atrial pathology and...

This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), funds research at the University of California, Davis to investigate the role of calcium dysregulation in human atrial fibroblasts and its contribution to atrial fibrosis in atrial fibrillation. The $570,537 award, effective from January 1, 2025 to December 31, 2028, supports direct measurements of ion channels and calcium regulators in human atrial...

This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $1,283,558 to the Massachusetts Institute of Technology (MIT) to develop multi-electroplasmonic nanoantenna arrays (MENAS) for wireless transmembrane-level recording of cardiomyocyte action potentials with sub-micrometer resolution. The goal is to create a breakthrough technology that will enable fundamental and pharmacological studies of cardiovascular systems at...

This $810,964 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) program, supports the development of a novel non-invasive 3D mapping technique to accurately identify the site of origin for ventricular tachycardia (VT) and premature ventricular complexes (PVCs) using 12-lead ECG data. The project aims to create a computerized method that can automatically locate the VT exit/PVC origin site in real-time,...

This $275,000 Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development and validation of an automated method for continuous post-operative cardiac rhythm diagnosis. The project, led by Atrility Medical, Inc., aims to improve the accuracy and accessibility of post-operative rhythm monitoring through the use of high-quality atrial electrogram signals. The anticipated outcome is a real-time, continuous...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop a flexible bioelectronic microarchitecture that integrates a capillary-like delivery network and a tissue-like sensing network to improve cardiac tissue engineering. The $488,026 award supports the creation of a system that can efficiently deliver media and provide real-time physiological feedback to enhance the development of...

This Project Grant award from the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) provides $199,992 to Boston University to develop a high-throughput electrical stimulation screening platform for assessing the long-term effects of cardiac contractility modulation (CCM) devices on engineered human heart tissue. The project will support a postdoctoral scholar co-mentored by researchers at the Food and Drug Administration (FDA) and Boston University to advance...