Project Grant 20266701546734
- The National Institute of Food and Agriculture awarded Texas A&M Agrilife Research $650,000 on February 1, 2026, under the Agriculture and Food Research Initiative (AFRI) Foundational and Applied Science Program to investigate the genetic contributions of male and female parents to pregnancy establishment and maintenance in cattle, with particular focus on embryonic mortality during days 28–60 of gestation. The research addresses late-stage embryonic loss, which occurs in approximately 12...
- The Department of Agriculture National Institute of Food and Agriculture awarded Washington State University $300,000 on February 1, 2026, under the Agriculture and Food Research Initiative (AFRI, CFDA 10.310) to conduct research on parent-specific epigenetic modifications in the bovine placenta and their role in pregnancy establishment and maintenance in dairy cattle. The project addresses pregnancy loss in dairy heifers, a leading cause of premature exit from production systems with industry...
- The Department of Agriculture's National Institute of Food and Agriculture awarded a $120,000 Project Grant under the Agriculture and Food Research Initiative competitive grants program to Virginia Polytechnic Institute & State University from July 2021 through June 2023. The grant funds research to investigate embryonic losses occurring during blastocyst hatching and embryo elongation in cattle, which can significantly impact the cattle industry. The principal investigator will...
- The Department of Agriculture National Institute of Food and Agriculture awarded Washington State University $193,277.19 under the Agriculture and Food Research Initiative (AFRI, CFDA 10.310) on July 15, 2026, to investigate how pregnancy-associated glycoproteins (PAGs) secreted by the bovine placenta modulate maternal immune responsiveness and promote embryo tolerance during the critical period of placental attachment. The research addresses pregnancy failure, which affects approximately 50...
- The Department of Agriculture National Institute of Food and Agriculture awarded Cornell University $300,000 on March 1, 2026, under the Agriculture and Food Research Initiative (AFRI), Assistance Listing 10.310, to investigate the molecular mechanisms driving early embryonic gene activation in cattle. Cornell will map the timing and location of histone acetylation (H4K16ac) on DNA-packaging proteins during the first days after fertilization, and determine the developmental consequences when the...
- The Department of Agriculture National Institute of Food and Agriculture awarded $650,000 to Virginia Polytechnic Institute & State University on February 1, 2026, under the Agriculture and Food Research Initiative (AFRI, CFDA 10.310) to investigate interleukin-6 family signaling proteins and their roles in early embryonic development and pregnancy establishment in cattle. The research has three specific aims: determine how IL6-family signals guide early embryo formation, particularly the...
- The Department of Agriculture National Institute of Food and Agriculture awarded Colorado State University $180,000 on May 1, 2026, under the Agriculture and Food Research Initiative (AFRI, CFDA 10.310) to evaluate bovine embryo quality using genetic and epigenetic analysis prior to transfer. The research will examine whether embryos of varying quality display distinct methylation patterns and whether invasive biopsy methods alter these patterns, with the goal of improving embryo selection to...
- The Department of Agriculture National Institute of Food and Agriculture awarded $299,440 to the University of Missouri System on May 1, 2026, under the Agriculture and Food Research Initiative (AFRI, CFDA 10.310) to conduct research on reproductive and genomic technologies for beef cattle breeding systems. The award supports research aimed at increasing adoption of genomic testing and artificial insemination—particularly sex-sorted semen—within commercial beef operations to enable precision...
- The Department of Agriculture National Institute of Food and Agriculture awarded Purdue University $650,000 under the Agriculture and Food Research Initiative (AFRI) on February 1, 2026, to investigate trophoblast Kunitz domain proteins (TKDPs) and their role in early pregnancy maintenance and embryo-uterine communication in cattle. The project addresses early pregnancy loss, a major cause of reduced fertility and productivity in beef and dairy herds. Researchers will examine how...
- The Department of Agriculture National Institute of Food and Agriculture awarded Virginia Polytechnic Institute & State University $225,000 on December 1, 2025, under the Agriculture and Food Research Initiative (AFRI) Foundational and Applied Science Program (CFDA 10.310) to conduct research on embryokine supplementation and inhibition in cattle in vitro embryo production. The research combines laboratory and applied approaches to determine whether supplementing or inhibiting...
The Department of Agriculture National Institute of Food and Agriculture awarded Oklahoma State University $300,000 on September 15, 2026, under the Agriculture and Food Research Initiative (AFRI) to identify imprinted genes in cattle embryos during early pregnancy and map their parent-of-origin-dependent activity across developmental stages. The project addresses early pregnancy failure in beef and dairy cattle, which costs producers billions annually. The research will breed Angus females to a Brahman bull to trace paternal and maternal gene copies, then collect embryos at four early developmental stages to measure gene expression in individual cells, examine DNA chemical marks controlling gene activity, and map gene activity distribution across the embryo. The deliverable is a detailed catalog of parent-of-origin gene activity during early cattle pregnancy and spatial mapping showing which embryo regions depend on paternally and maternally inherited genes. This work fills a gap in understanding why early bovine pregnancies fail; fewer than 50 imprinted genes have been confirmed in cattle compared with more than 150 in humans and mice. Performance occurs in Stillwater, Oklahoma, with a period of performance from September 15, 2026, through September 14, 2028. AFRI is a competitive research grants program supporting investigations in plant health and production, animal health and production, food safety and nutrition, bioenergy and natural resources, agriculture systems and technology, and rural economics. The assistance type is a project grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $300.0k | 8/19/26 |