** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE GOAL OF THIS STUDY IS TO DELINEATE EVIDENCE AND MECHANISMS BY WHICH THE ANTHOCYANIN-ENRICHED TRANSGENIC TOMATOES MAY PROTECT AGAINST COLORECTAL CANCER THROUGH ANTHOCYANINS IN CELL CULTURE AND ANIMAL MODELS. SUCCESSFUL COMPLETION OF THIS STUDY WILL PROVIDE SCIENTIFIC EVIDENCE FOR THE HEALTH BENEFITS OF ANTHOCYANIN-ENRICHED BIOENGINEERED TRANSGENIC TOMATOESFOR ANTICANCER ACTIVITIES. IN ADDITION, THIS STUDY WILL ENCOMPASS REGULAR PUBLICATIONS IN REPUTABLE JOURNALS AND TRAIN POSTDOCTORAL FELLOW AND GRADUATESTUDENTS. ANOTHER IMPORTANT IMPACT OF THIS WORK IS TO PROMOTE AGRICULTURAL FARMING AND MARKETING OPPORTUNITIES FOR NOVEL TOMATO VARIETIES AS FUNCTIONAL FOOD PRODUCTS FOR CANCER PREVENTION.