Project Grant R01AI178885

Award Date 7/5/24
Completion Date 6/30/29
Dollars Obligated $817K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Fort Collins, CO 80521, USA
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  1. Manufacture and characterize larger quantities of the spectinamide compound DP1810 for inhalation therapy,
  2. Determine the optimal dosing regimen for DP1810 in combination with other TB drugs like bedaquiline, pretomanid, and pyrazinamide,
  3. Evaluate the efficacy and sterilization potential of these new inhalational TB drug regimens in animal models, and
  4. Conduct toxicology studies to support IND filing.

Two key sub-awards are provided to the University of Tennessee to support pharmacokinetic modeling and dose projections, and to RTI International to manufacture and characterize the spectinamide dry powder formulation. This initiative aims to advance shorter, simpler, and safer TB treatment regimens through the integration of spectinamides delivered directly to the lungs.

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